The Gastrointestinal Research Group
Professor, Department of Physiology & PharmacologyInflammation Research Network
B.Sc, Queen's University
M.Sc, Queen's University
Ph.D, Queen's University
Inflammatory diseases of the gastrointestinal tract are associated with a variety of symptoms including pain, diarrhea, and malabsorption among others. We are investigating various aspects of mucosal inflammation, concentrating on the role of the epithelium in the intestinal inflammatory response. Specifically, we are involved in investigations of the role of nitric oxide, prostaglandins and protease-activated receptors in alterations of host defence mechanisms; dysfunctions which could lead to relapse of disease or exacerbation of inflammation in Inflammatory Bowel Disease. In addition, we are investigating the link between inflammation and cancer, focusing on how mutations in the β-catenin transcription pathway alter epithelial responses to inflammatory mediators. Finally, secretion of water is an important component of the role of the epithelium in host defence, so we are studying the regulation of aquaporin expression to see how these water channels may play a role in inflammation-induced epithelial dysfunction.
Hyland, N.P., J.M. Rybicka, W. Ho, Q.J. Pittman, W.K. MacNaughton and K.A. Sharkey. 2010. Adaptation of intestinal secretomotor function and nutrient absorption in response to diet-induced obesity. Neurogastroenterology and Motility. 22:602-e171.
Storr, M.A., M. Bashashati, C. Hirota, V.K. Verumi, C.M. Keenan, M. Duncan, B. Lutz, K. Mackie, A. Makriyannis, W.K. MacNaughton and K.A. Sharkey. 2010. Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice. Neurogastroenterology and Motility. 22:787-796, e223.
Wang, H., F. Moreau, C.L. Hirota and W.K. MacNaughton. Proteinase-activated receptors induce interleukin-8 expression in intestinal epithelial cells through ERK/RSK90 activation and histone acetylation. FASEB Journal. 24:1971-1980.
Ohland, C.L., W.K. MacNaughton. Probiotic bacteria and intestinal epithelial barrier function. American Journal of Physiology: Gastrointestinal and Liver Physiology. 298:G807-G819.
Swystun V.A., B. Renaux, F. Moreau, S. Wen, M.A. Peplowski, M.D. Hollenberg and W.K. MacNaughton. Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase C zeta. American Journal of Physiology: Gastrointestinal and Liver Physiology. 297:G60-G70.
van der Merwe, J.Q., F. Moreau and W.K. MacNaughton. Protease-activated receptor-2 stimulates intestinal epithelial chloride transport through activation of PLC and selective PKC isoforms. American Journal of Physiology: Gastrointestinal and Liver Physiology. 296:G1258-G1266.
Wang, H., R. Zhang, S. Wen, D.-M. McCafferty, P.L. Beck and W.K. MacNaughton. 2009. Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. Journal of Molecular Medicine. 87:435-445.