Airway Inflammation Research Group
Physiology & Pharmacology
Telephone number: 403.210.8562
Email address: email@example.com
Primary Institute: Snyder Institute for Chronic Diseases
The principal research focus of my laboratory is the elucidation of the mechanism of action of existing and novel anti-inflammatory therapies for the treatment of chronic obstructive pulmonary disease (COPD), asthma and allied respiratory conditions that are characterized by chronic inflammation. Specifically, these include phosphodiesterase (PDE) 4 inhibitors, inhaled corticosteroid (ICS)/long-acting 2-adrenoceptor agonist (LABA) combination therapies and novel targets such as activators of the nuclear hormone receptor, peroxisome proliferator-activated receptor (PPAR). More recently, in collaboration with the Department of Chemistry (U of C), we have used crystallography-driven computational chemistry to identify, optimize and synthesize a novel series of PDE inhibitors based on a lead isoxazolopyridazinone derivative. These compounds may have unique anti-inflammatory activity and their study has formed a novel research activity that could provide new insights into better ways of treating airways inflammation.
Techniques used in Dr. Giembycz's laboratory:
Cell culture, ELISA, real-time RT-PCR, western blotting, promoter-luciferase constructs, receptor over-expression, electrophoretic mobility shift assays, siRNA knockdown, in vitro and in vivo pharmacology, classical enzymology, radioligand binding.
Tiziana (Tiz) Reiter
Phone number: 403.210.6766