Sept. 23, 2019

Study shows MRI can help remove DOUBT when diagnosing minor strokes

Diagnosis changed for 30 per cent of patients in the study based on the MRI scan

A University of Calgary-led international study is highlighting the importance of magnetic resonance imaging (MRI) in helping to diagnose minor stroke and transient ischemic attacks (TIAs).

The six-year study, which included researchers from hospitals in Canada, Australia and the Czech Republic, involved 1,028 patients who experienced a number of symptoms that aren’t always associated with stroke — such as numbness, dizziness, or very short episodes of weakness or difficulty with speech.

Principal investigator Dr. Shelagh Coutts, MD, in photo above, a member of the Cumming School of Medicine’s (CSM) Hotchkiss Brain Institute, and a neurologist at Alberta Health Services’ Foothills Medical Centre, says that, because the risk of stroke increases after a first TIA, it is important that physicians are certain of the diagnosis in low-risk cases with non-traditional symptoms.

Patients with motor or speech symptoms lasting more than five minutes are at high risk of having a stroke and must been seen urgently. The problem is that over 50 per cent of patients with possible symptoms of a TIA do not have these symptoms.

“If you don't have motor and speech symptoms, the diagnosis is a lot less clear — so patients with numbness, dizziness or with difficulty walking may not be diagnosed with a stroke syndrome. These patients are, overall, felt to be at low-risk of having stroke,” says Coutts, a professor in the departments of Clinical Neurosciences, Radiology, and Community Health Sciences at the CSM.

Physicians involved in the study group — Diagnosis of Uncertain-Origin Benign Transient Neurological Symptoms (DOUBT) — examined patients within eight days of the start of their symptoms. They performed a detailed neurological assessment, took a patient history, made a diagnosis, and then did an MRI scan within the first week — followed by a second diagnosis.

“We found in this study that there was a 13-per-cent risk of having had a stroke,” adds Coutts.  “This was far higher than we expected in this low risk population.”

Further, in 30 per cent of patients in the study, the physicians changed their diagnosis based on the MRI scan.

“That's not just to change patients to having a stroke,” notes Coutts. “There's also the reverse where we thought they might have had a stroke or TIA but based on a negative MRI scan (and other clinical symptoms) we decided it wasn't.”

In many patients with minor stroke or TIA, Coutts says that symptoms are straightforward and a stroke can be diagnosed — or ruled out — without the need for MRI scans.

“In a patient in whom it is quite clear to the physician treating them that they have had a transient ischemic attack, then usually an MRI scan isn't actually that helpful. The MRI is really useful in patients in whom we are unclear what the diagnosis is.”

And from a patient perspective (if the MRI is negative), knowing they haven't had a TIA is very important, she says, as it reduces the use of unnecessary medication.

“The MRI can be done in the first week as an outpatient,” notes Dr. Michael Hill, MD, a co-author of the paper, and neurologist at Alberta Health Services’ Foothills Medical Centre and member of the CSM’s Hotchkiss Brain Institute and the O’Brien Institute for Public Health.

“It is not an emergency, same-day test. The MRI has an important predictive value.  A normal test means that the patient most likely has not suffered a stroke syndrome and the risk of future stroke is very, very low,” adds Hill, a professor in the departments of Clinical Neurosciences, Community Health Sciences, Medicine, and Radiology, at the CSM.

The findings were published Sept. 23, in the journal JAMA Neurology. Funding for the study was provided by the Canadian Institutes for Health Research.

Led by the Hotchkiss Brain InstituteBrain and Mental Health is one of six research strategies guiding the University of Calgary in its Eyes High strategic direction. The strategy provides a unifying direction for brain and mental health research at the university and positions researchers to unlock new discoveries and treatments for brain health in our community.