A Prospective Approach to Disease progression, Treatment Response and Quality of Life in Eosinophilic Esophagitis
Summary
Eosinophilic esophagitis (EoE) is a condition of the esophagus i.e. our food pipe resulting in problems such as the feeling of food getting stuck in your food pipe (dysphagia) and acid reflux (GERD). This condition arises in patients as a result of ongoing inflammation caused by an immune cell called eosinophils in the esophagus due to allergens from food or air.
The occurrence of EoE is increasing, a recent research study found the prevalence of EoE in Calgary, Canada to be 10.7 to 33.7 cases per 100,000 individuals. EoE is found around the globe both in developed and developing countries.
Currently, EoE is routinely treated with drugs that suppress the inflammation in the esophagus (oral corticosteroids) or by avoidance of allergenic foods (dietary elimination) and by the medical procedure to increase the diameter of esophagus i.e. the food pipe so food will move down the stomach easily (endoscopic dilation).
Avoiding allergenic food by patients to reduce inflammation is very complex and hard to follow because to find out the right allergen, following the diet for a long time and also a consideration on the nutrition leads to poor life quality. Hence there is an urgent need to have a standardized and well-balanced plan for the treatment of patients with EoE.
This study is looking to study 1000 patients over a period of 15 years to see which treatment plan is ideal.
Eligibility
Eligible gender: Male, Female, Transgender, Other
Eligible ages: 18 to 60
Inclusion criteria:
1. Adult, 18 years and older
2. Confirmed diagnosis of eosinophilic esophagitis from GI specialist
3. Patients having symptoms related to esophageal dysfunction
Exclusion criteria:
1. Patients with other eosinophilic disorders in other parts of the alimentary tract e.g. stomach or infection or hypereosinophilic syndrome
2. Patients with Crohn's disease,
3. Patients with Connective tissue disease
4. Known diagnosis of other esophageal diseases such as Nutcracker/Jackhammer, achalasia
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Additional information
Contact information
Physician referral
Principal investigator:
Milli Gupta
Clinical trial:
No
REB-ID:
REB18-0733