Does increased carbon dioxide (CO2) make patients with Neurogenic Orthostatic Hypotension feel better?
Summary
We are studying if increased carbon dioxide (CO2) can increase blood pressure and reduce symptoms in patients with Neurogenic Orthostatic Hypotension (NOH) and healthy volunteers. Participants will perform four active stand tests under different CO2 levels. We will monitor blood pressure, heart rate, and brain blood flow to determine which intervention is the most effective in minimizing symptoms and improving blood pressure. We will also take pictures of the blood vessels in the eye to better understand changes happening close to the brain
Eligibility
Eligible gender: Male, Female, Transgender, Other
Eligible ages: 18 to 100
Accepts healthy participants: Yes
Inclusion criteria:
1- NOH diagnosis OR Healthy volunteers
2- Over 18 years old
3- Non-smoking
4- Able and willing to provide informed consent.
Exclusion criteria:
1 - Has not being diagnosed with NOH by a physician (patients only)
2 - Inability to tolerate a mask during the study
3 - Require portable oxygen at rest or with exercise
4 - Heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.
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Additional information
Contact information
Post-doctoral Fellow: Dr. Jacquie Baker
Principal investigator:
Satish Raj
Clinical trial:
No
REB-ID:
REB20-1322