Biomarkers and Mild Behavioural Impairment (BAMBI)
Summary
This study enrolls community dwelling older adults for assessments of cognition, behaviour, function, quality of life, and caregiver stress, in association with biomarkers, at 18 month intervals. Participants attend with a study partner, and at each visit are given a series of questionnaires and tests. The overall visit is ~2.5 hours in duration. Biomarkers of inflammation and neurodegeneration are obtained via a participant blood draw and urine collection at each visit. Additionally, participants will be given a stool collection kit to take home which will be returned to the lab for gut microbiome analysis.
Eligibility
Eligible gender: Male, Female, Transgender, Other
Eligible ages: 60 to 99
Accepts healthy participants: Yes
Inclusion criteria:
1. Age 60 or older with normal cognition, subjective cognitive decline, mild cognitive impairment, or mild AD dementia.
2. Study partner available who has known the participant for ≥5 years
Exclusion criteria:
1. Developmental disorders and neuropsychiatric conditions that would affect testing (e.g., autism, Huntington’s disease, schizophrenia, bipolar disorder)
2. Unable to provide informed consent
3. No study partner
4. Not fluent in English
Participate
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Collection of personal information
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the authority of section 33(c) of the Freedom of Information and Protection of Privacy Act. If
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Additional information
Contact information
Ramnik Brar
Principal investigator:
Zahinoor Ismail
Clinical trial:
No
REB-ID:
REB21-1463