Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant Depression: A randomized double-blind sham- controlled pilot study
Summary
Transcranial magnetic simulation (TMS) is a non-invasive stimulation treatment applied over scalp for people with major depression. This study explores whether theta-burst TMS, a newer form of TMS is effective as a treatment in patients with depression. Participants will be assigned to either receive real TMS therapy or a placebo version (sham stimulation), and participants will not know who received what. Then participants will undergo approximately three real TMS or placebo stimulation sessions a day for 10 days in 2 weeks ( total 30 sessions). At the end of the 4 weeks, participants will be assessed to see how their depressive symptoms may have changed.
Eligibility
Eligible gender: Male, Female, Transgender, Other
Eligible ages: 18 to 65
Inclusion criteria:
To be involved in this study, participants must:
1. be aged 18-65
2. have a diagnosis of unipolar major depressive disorder
3. have failed to respond to at least one antidepressant
Exclusion criteria:
Participants must not:
1. have Psychosis, Manic depression or Bipolar depression, Substance abuse
2. have severe neurological diseases : epilepsy, stroke, dementia, Parkison’s disease, multiple sclerosis
3. be pregnant
Participate
Additional information
Contact information
Principal study Psychiatrist. No professional referral is required.
Principal investigator:
Rajamannar Ramasubbu
Clinical trial:
Yes
REB-ID:
REB22-1547