Exploring the connections between chronic fatigue, behaviour, and gut microbiome dysbiosis in children with neurodevelopmental disorders
Summary
Background
Every person has healthy bacteria, called microbes, that are with them from the time they are born. These microbes usually help keep us healthy. The ones that help us digest our food are called the gut microbiome. We are interested in how the gut microbiome impacts fatigue and behaviour for children and youth with neurodevelopmental disorders. We are asking youth with neurodevelopmental disorders (NDDs) and their siblings to provide stool and breath samples that can be analyzed for biomarkers. The goal of this study is to validate our protocols for biomarker identification. The overall purpose of this research study is to understand the interaction between the gut microbiome and co-occurring conditions in NDDs such as fatigue and behaviours of concern. Ultimately, these biomarkers may help in early diagnosis and developing new treatments.
Roles and Responsibilities
As part of this study, your children will be asked to provide stool and breath samples at 3 different time points. We will also ask you some questions about your children’s health, sleep, and behaviour.
Time Commitment
The total time commitment is anticipated to be 15-20 hours over the course of 6 months with 3 study visits to the Alberta Children’s Hospital in Calgary.
Compensation/Reimbursement
Compensation will be offered at rate of $50 per study visit per child; $150 total per child, $300 for each sibling pair.
Eligibility
Eligible gender: Male, Female, Transgender, Other
Eligible ages: 3 to 18
Accepts healthy participants: Yes
Inclusion criteria:
1. Child or youth ages 3 to 18 years old AND
2. Diagnosis of a neurodevelopmental disorder (e.g., Autism, ADHD, intellectual disability) AND
3. Behaviours of concern AND
4. Chronic fatigue OR
5. Sibling of a child or youth who meets the above eligibility requirements
Participate
Fill out the following form if you want to participate in this research
Collection of personal information
Your personal information is collected under
the authority of section 33(c) of the Freedom of Information and Protection of Privacy Act. If
you have any questions about the collection or use of this information, please visit our
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Additional information
Contact information
Dr. Sarah MacEachern
Principal investigator:
Sarah MacEachern
Clinical trial:
No
REB-ID:
REB23-0863