Morley D. Hollenberg, D Phil, MD
BSc (Honours, Chemistry) University of Manitoba
MSc (Chemistry) University of Manitoba
D Phil (Pharmacology) Oxford University
MD Johns Hopkins University School of Medicine
Internship (Internal Medicine) Johns Hopkins Hospital
Professor
Department of Physiology and Pharmacology and
Department of Medicine
3330 Hospital Drive NW
Calgary, Alberta, Canada T2N 4N1
Phone: (403) 220-6931
Fax:
(403) 270-0979
Email:
mhollenb@ucalgary.ca
RESEARCH
|
My research
interests over time have focused on the biosynthesis and actions of peptide
hormones (oxytocin, vasopressin, insulin, epidermal growth factor) and on
the molecular pharmacology and pathophysiology of receptor-mediated
signaling by growth factors and G-protein coupled receptors (GPCRs). This
focus seeks to understand rapid events occurring in tissues like smooth
muscle, responsible for the regulation of blood vessel and intestinal
motility. Recent work is studying the hormone-like signaling properties of
proteinases that act in part via the ‘proteinase-activated receptor (PAR)’
family of GPCRs. The PARs regulate diverse pathophysiological processes
ranging from vascular angiogenesis and contractility to arthritic and
intestinal inflammation and pain. As one major focus, we are studying the
activation of these receptors (PARs 1, 2 and 4) by thrombin, trypsin and
other serine proteinases, like the tumour-derived tissue kallikrein family.
We are particularly interested in the signalling pathways for the PARs that
are in common with those for growth factor receptors, resulting in the
activation of cellular tyrosine kinase pathways in the vasculature and other
target tissues. A major direction related to signaling by proteinases seeks
to identify, with the use of activity-based covalent proteinase labeling
probes and proteomic analysis, those serine proteinases responsible for
regulating cell and tissue function via the PARs in the settings of health
and disease. |
| View PubMed Listings for Morley D. Hollenberg |
Administrative Assistant
Dawn Malus
Tel:
(403) 220-3035
Email:
endosec@ucalgary.ca