University of Calgary : Biochemistry BCEM


Site Navigation
Welcome
Important Notice and Disclaimer
Academic Schedule
Types of Credentials and Sub-Degree Nomenclature
Undergraduate Degrees with a Major
Combined Degrees
Minor Programs
Student and Campus Services
Admissions
Academic Regulations
Co-operative Education/Internship
Tuition and General Fees
Awards and Financial Assistance
International Foundations Program
Faculty of Arts
Cumming School of Medicine
Faculty of Environmental Design
Faculty of Graduate Studies
Haskayne School of Business
Faculty of Kinesiology
Faculty of Law
Faculty of Nursing
Qatar Faculty
Schulich School of Engineering
Faculty of Science
Faculty of Social Work
Faculty of Veterinary Medicine
Werklund School of Education
Embedded Certificates
Continuing Education
COURSES OF INSTRUCTION
How to Use
Courses of Instruction by Faculty
Course Descriptions
A
B
Biochemistry BCEM
Biology BIOL
Biomedical Engineering BMEN
Biostatistics BIST
Botany BOTA
Business and Environment BSEN
Business Technology Management BTMA
C
D
E
F
G
H
I
J, K
L
M
N, O
P
R
S
T, U
V, W, Z
About the University of Calgary
Who's Who
Glossary of Terms
Contact Us
Archives
University of Calgary Calendar 2018-2019 COURSES OF INSTRUCTION Course Descriptions B Biochemistry BCEM
Biochemistry BCEM

Instruction offered by members of the Department of Biological Sciences in the Faculty of Science.

Students interested in taking Biochemistry courses are urged to read the advice in the Faculty of Science Program section of this Calendar.

†Limited amounts of non-scheduled class time involvement will be required for these courses.

Senior Courses
Biochemistry 341       Biochemistry of Life Processes
Emphasis is placed on describing the chemistry of biochemical molecules including proteins, carbohydrates, lipids, and nucleic acids, and how this relates to cell structure and life processes. Basic concepts of metabolism are introduced, focusing on the breakdown of carbohydrates for energy. The laboratory component reinforces learning of the lecture material, while teaching technical skills and the analysis and interpretation of experiments involving biochemical molecules.
Course Hours:
3 units; H(3-3/2)
Prerequisite(s):
Chemistry 351.
Antirequisite(s):
Not open to majors in the Department of Biological Sciences or Natural Sciences concentrators in Biological Sciences. Credit for Biochemistry 341 and 393 will not be allowed.
back to top
†Biochemistry 393       Introduction to Biochemistry
Biomolecules and metabolism as a foundation for understanding molecular organization and reactions of life. Relationships between structure and biological function of amino acids, proteins, lipids, nucleic acids and coenzymes. Principles of metabolism are illustrated using key metabolic pathways. Laboratory involves inquiry-based approaches for studying biomolecules and metabolic pathways.
Course Hours:
3 units; H(3-3/2)
Prerequisite(s):
Chemistry 351; and Biology 311 or admission to the BHSc Honours program and Medical Sciences 341.
Antirequisite(s):
Credit for Biochemistry 393 and 341 will not be allowed.
Notes:
Prior or concurrent completion of Biology 331 is strongly recommended.  Biochemistry 393 and 443 are the recommended courses for students wishing to take only two biochemistry courses.
back to top
Biochemistry 401       Biochemistry Laboratory Techniques I
Recombinant DNA techniques, protein expression and mutagenesis stressing nucleic acid and protein properties relevant to these techniques. Practical experience in the laboratory includes DNA amplification (PCR), gene cloning and expression, nucleic acid-protein bioinformatics and introduction to methods for working with proteins. Emphasis on the scientific process: experimental design, data analysis and dissemination of results.
Course Hours:
3 units; H(3-6)
Prerequisite(s):
Biochemistry 393 and one of Chemistry 353 or 355.
Antirequisite(s):
Credit for Biochemistry 401 and Cellular, Molecular and Microbial Biology 451 will not be allowed.
back to top
Biochemistry 403       Biochemistry Laboratory Techniques II
Chromatography, protein purification, biophysical and enzymatic means of characterizing proteins. Practical experience in the laboratory with protein purification and protein characterization techniques selected to complement the selection from Biochemistry Laboratory Techniques I.
Course Hours:
3 units; H(3-6)
Prerequisite(s):
Biochemistry 401 and 471.
back to top
Biochemistry 431       Proteins and Proteomics
Protein structure and chemistry: structural motifs, ligand-binding, conformational changes, chemical modification; protein folding; structure prediction by molecular modelling. Identification of proteins in the proteome: 2D gel electrophoresis and chromatography, mass spectrometry; metalloproteins; post-translational modifications; protein-protein interactions.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biology 331, Biochemistry 393 and one of Chemistry 353 or 355.
Antirequisite(s):
Credit for Biochemistry 431 and 531 will not be allowed.
back to top
Biochemistry 443       Metabolism and Basic Nucleic Acid Biochemistry
Intermediary carbohydrate, lipid and nitrogen metabolism, and the regulation of these metabolic pathways; nucleic acid chemistry, structure, stability and enzymatic processing.
Course Hours:
3 units; H(3-4/2)
Prerequisite(s):
One of Chemistry 353 or 355; and Biochemistry 341 or 393.
Notes:
Not required for majors in the Biochemistry program. Biochemistry 393 and 443 are the recommended courses for students wishing to take only two biochemistry courses.
back to top
Biochemistry 471       Physical Biochemistry
The laws of thermodynamics as they apply to biological systems: the hydrophobic effect, properties of water, electrolyte solutions and ligand binding. Optical spectroscopic methods including UV/visible absorption, fluorescence, and infrared as applied to biological molecules.
Course Hours:
3 units; H(3-2T)
Prerequisite(s):
Biochemistry 341 or 393; Chemistry 353 or 355; one of Mathematics 249, 251, 265, 275, 281, or Applied Mathematics 217 and one of Mathematics 253, 267, 277, 283, 211, 213, or Applied Mathematics 219; and Physics 211 or 221, and 223.
back to top
Biochemistry 507       Special Problems in Biochemistry
Independent research or reading project that may include seminars, lectures, term papers and training in theoretical and/or laboratory methods.
Course Hours:
3 units; H(0-8) or H(3-0)
Prerequisite(s):
54 units (9.0 full-course equivalents) and consent of the Department.
Notes:
Students completing a typical course sequence in their program would normally be eligible to enrol in their third or fourth year. After consultation with a departmental faculty member who will supervise the chosen problem, a permission form obtained from the department office or website must be signed by the course supervisor before a student can register.
MAY BE REPEATED FOR CREDIT
back to top
Biochemistry 528       Independent Studies in Biochemistry
Original and independent thought, practical research and the completion of written and oral reports.
Course Hours:
6 units; F(0-8)
Prerequisite(s):
72 units (12 full-course equivalents) and consent of the Department.
Notes:
After consultation with a departmental faculty member who will supervise the chosen problem, a permission form obtained from the department office or website must be signed by the course supervisor before a student can register.
MAY BE REPEATED FOR CREDIT
back to top
Biochemistry 530       Honours Research Project in Biochemistry
Research project under the direction of one or more faculty members in the Department of Biological Sciences. Formal written and oral reports must be presented on completion of this course. Open only to Honours Biochemistry students or Honours Biological Sciences students.
Course Hours:
6 units; F(0-8)
Prerequisite(s):
Biochemistry 403, 72 units (12 full-course equivalents) and consent of the Department.
Notes:
After consultation with a department faculty member who will supervise the chosen problem, a permission form obtained from the department office or website must be completed before a student can register.
back to top
Biochemistry   541       Biochemical Toxicology
An interdisciplinary course focused on the diverse biomolecular mechanisms by which organic (e.g. PCB’s) and inorganic pollutants (e.g. Cd, Hg, As) adversely affect cell function examined at multiple levels of organization, from molecules to whole animals organisms. Topics include how natural toxins exert toxicity, how toxins/light generate free radicals within cells, how the speciation of metals in the environment affects their bioavailability/toxicity, and the toxicity mechanisms that lead to homeostatic dysfunction.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 341 or 393; Chemistry 311, 321 and 351.
Also known as:
(Chemistry 541)
back to top
Biochemistry 543       Enzymology
The structure, mechanisms and biological interactions of enzymes. Binding, catalysis, rates and regulation will be discussed with regard to chemical principles of kinetics and reaction. The principles of enzyme action will be considered in the context of the biological role that enzymes play.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 393 or 443.
back to top
Biochemistry 547       Signal Transduction and Regulation of Metabolism
Principles of signal transduction with examples from prokaryotes and eukaryotes. Discussion of protein covalent modifications, inositol lipid signaling, structure and function of protein kinases and protein phosphatases and their role in regulating various aspects of cell function. Emphasis on metabolic pathways, cell cycle control, checkpoints, DNA damage response and epigenetics.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 393 or 443.
back to top
Biochemistry 551       Structural Biology
Applications of modern methods to structural studies of proteins and nucleic acids by NMR and X-ray crystallography with a comparison of the structural information derived from the two methods. Crystallization of macromolecules. Experimental and theoretical foundations of X-ray and NMR structure determination, and ligand binding. Non-invasive NMR studies of metabolism, and magnetic resonance imaging.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
One of Biochemistry 341 or 393; and one of Biochemistry 471 or Chemistry 371.
back to top
Biochemistry 553       Molecular Biophysics
A comprehensive survey of modern biophysics covering the flow and processing of matter, energy and information in living systems. Equilibrium and non-equilibrium thermodynamics in biology. Molecular motors and facilitated proton transport. An integrative approach connecting atomistic theories to cellular processes.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 341 or 393; and Biochemistry 471 or Chemistry 371.
Notes:
Prior completion of Biochemistry 555 is strongly recommended.
Also known as:
(formerly Biology 553)
back to top
Biochemistry 555       Biomembranes
The material examines the structure and function of biological membranes with a strong emphasis on the role of membrane proteins. Topics may include: the physical properties of lipid bilayers, isolation and purification of membrane proteins, preparation of membrane mimetic systems, ion and solute movement across membranes (transport and ion channels), membrane protein folding, assembly and structure, and protein secretion and translocation systems.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 431 and 471 and one of 393 or 443.
back to top
Biochemistry 561       Applied Biochemistry and Biotechnology
An introduction to the language, materials, methods, concepts and commercial applications of biotechnology with emphasis on methodology, proteins as products, and the impact of genome sequencing on biotechnology. Topics will also include microbial, animal, and bioremediation biotechnology, expanding the genetic code, synthetic biology, antibiotic resistance, cancer immunotherapy, stem cells, and gene therapy.
Course Hours:
3 units; H(3-0)
Prerequisite(s):
Biochemistry 393.
Notes:
Prior completion of Cellular, Molecular and Microbial Biology 411 or Biochemistry 401 is strongly recommended.
back to top
Biochemistry 575       Lipids
Structure and function of lipids including phospholipids, sphingolipids, and steroids. Topics include properties of lipids and bilayers, lipid-lipid and lipid-protein interactions, technological applications, biosynthesis and regulation, lipids as second messengers, intracellular trafficking, and lipids in physiology and disease. Literature review and student seminars are significant components of this course.
Course Hours:
3 units; H(3-1T-0)
Prerequisite(s):
Biochemistry 393 and one of Biochemistry 401 or 443.
back to top
Biochemistry 577       Biomolecular Simulation
Introduction to simulation and computer modelling methods commonly used in biochemistry and biophysics, with a focus on physical models to understand the behaviour of biomolecules. Topics include simulation methods, dynamics of proteins, DNA, and lipids, calculation of binding constants, protein-drug interactions, properties of ion channels as well as a number of recent literature topics.
Course Hours:
3 units; H(3-4)
Prerequisite(s):
One of Biochemistry 341 or 393 and one of Biochemistry 471 or Chemistry 371.
back to top
Graduate Courses

Enrolment in any graduate course requires consent of the Department.

Only where appropriate to a student's program may graduate credit be received for courses numbered 500-599.

600-level courses are available with permission to undergraduate students in the final year of their programs.

See also the separate listing of graduate level Chemistry courses.

Biochemistry 641       Selected Topics in Biochemistry
Selected topics in Biochemistry such as those which appear annually in the serial publication Annual Review of Biochemistry.
Course Hours:
3 units; H(3-0)
MAY BE REPEATED FOR CREDIT
back to top
Biochemistry 731       Current Topics in Biochemistry
A discussion of contemporary experimental and theoretical biochemical methods used for the study of drugs and diagnostics at a biomolecular level. Structural analysis, drug design and computational methods will be introduced, as well as modern 'omics' research approaches and current protein drug targets of the pharmaceutical industry.
Course Hours:
3 units; H(3-0)
back to top