Neurophysiology of Ion Channels We study the basis for neuronal excitability and long-term changes in the efficacy of synaptic transmission in mammalian cerebellum and hippocampus. Our work focuses on electrophysiology, imaging, and protein biochemistry to understand the physiological outcome of interactions between calcium channels and potassium channels. Work in cerebellum is now directed at the role of a calcium-potassium channel complex in dysfunction of synaptic plasticity in Fragile X Syndrome and the ability to restore function and reduce aberrant behaviours in a mouse model of Fragile X. Work in hippocampus is directed towards defining the members of a new tri-protein complex that allows different calcium sources to define the properties of one of the largest inhibitory responses in the brain.
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We are looking for students interested in electrophysiology, super resolution microscopy, and molecular biology to study the ionic basis for postsynaptic changes in neuronal excitability in Fragile X Syndrome and hippocampal signal processing.
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