Hossein is a Ph.D. candidate in the University of Calgary and his main research is aimed at integrating ultrasensitive and selective electrochemical nano-biosensors with a microfluidic platform for early diagnosis of dementia and traumatic brain injury diseases. The developed screening approach, he is working on, is well validated and enables low-cost, rapid, highly sensitive, and reliable detection of concussion in early stages. In this regard, he has designed a multi-layer nanocomposite for enhancing the sensitivity of the electrochemical sensor and developed a microchip for multiplexed detection of concussion-related biomarkers. Since the concentration of biomarkers rapidly changes over time, the real-time monitoring of the alteration is another approach which he is working on. The deliverable will be the first dedicated diagnostic point-of-care device for the early detection of concussion.
Supervisor: Amir Sanati Nezhad
Lab: BioMEMS and Bioinspired Microfluidic Laboratory
Funding: Eyes High Doctoral Recruitment Scholarship
R. Salahandish, A. Ghaffarinejad, E. Omidinia, H. Zargartalebi, K. Majidzadeh-A, Seyed M. Naghib, A. Sanati-Nezhad,” Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene” Biosensors and Bioelectronics, 120: 129-136, 2018.
R. Salahandish, A. Ghaffarinejad, Seyed M. Naghib, K. Majidzadeh-A, H. Zargartalebi, A. Sanati-Nezhad,” Nano-biosensor for highly sensitive detection of HER2 positive breast cancer”, Biosensors and Bioelectronics, 2018.