Prognosis (Outcome Prediction)

How do we predict which individuals will recover fully and which will experience persistent problems after concussion?

The ICRP will study a broad pool of neurobiological and psychosocial markers and their interactions as predictors of concussion outcomes. For example, we are examining multiple genes that are implicated in response to neurotrauma, neural repair and plasticity, and cognitive reserve, to see if some people are more susceptible or more resistant to the effects of concussion.



National Institute of Neurological Disorders and Stroke and Department of Defense Sport-Related Concussion Common Data Elements Version 1.0 Recommendations.

Broglio SP, Kontos AP, Levin H, Schneider K, Wilde EA, Cantu RC, Feddermann-Demont N, Fuller GW, Gagnon I, Gioia GA, Giza C, Griesbach GS, Leddy JJ, Lipton ML, Mayer AR, McAllister TW, McCrea M, McKenzie LB, Putukian M, Signoretti S, Suskauer SJ, Tamburro R, Turner M, Yeates KO,Zemek R, Ala'i S, Esterlitz J, Gay K, Bellgowan PSF, Joseph K.

J Neurotrauma. 2018 Dec 1;35(23):2776-2783. doi: 10.1089/neu.2018.5643. Epub 2018 Jul 23.


Cerebral blood flow in children and adolescents several years after concussion.

Brooks BL, Low TA, Plourde V, Virani S, Jadavji Z, MacMaster FP, Barlow KM, Lebel RM, Yeates KO.

Brain Inj. 2019;33(2):233-241. doi: 10.1080/02699052.2018.1540798. Epub 2018 Oct 31.


Predicting Psychological Distress after Pediatric Concussion.

Brooks BL, Plourde V, Beauchamp MH, Tang K, Yeates KO, Keightley M, Anderson P, Désiré N, Barrowman N, Zemek R; PERC Concussion Team.

J Neurotrauma. 2019 Mar 1;36(5):679-685. doi: 10.1089/neu.2018.5792. Epub 2018 Oct 10.


Using the Memory Validity Profile (MVP) to detect invalid performance in youth with mild traumatic brain injury.

Brooks BL, Sherman EMS.

Appl Neuropsychol Child. 2018 Jul 2:1-7. doi: 10.1080/21622965.2018.1476865. [Epub ahead of print]


Investigating Effects of Sex Differences and Prior Concussions on Symptom Reporting and Cognition Among Adolescent Soccer Players.

Brooks BL, Silverberg N, Maxwell B, Mannix R, Zafonte R, Berkner PD, Iverson GL.

Am J Sports Med. 2018 Mar;46(4):961-968. doi: 10.1177/0363546517749588. Epub 2018 Jan 11.


Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion.

Clough M, Mutimer S, Wright DK, Tsang A, Costello DM, Gardner AJ, Stanwell P, Mychasiuk R,Sun M, Brady RD, McDonald SJ, Webster KM, Johnstone MR, Semple BD, Agoston DV, White OB, Frayne R, Fielding J, O'Brien TJ, Shultz SR.

J Neurotrauma. 2018 Mar 1;35(5):730-738. doi: 10.1089/neu.2017.5204. Epub 2018 Feb 9.


Psychological Resilience as a Predictor of Persistent Post-Concussive Symptoms in Children With Single and Multiple Concussion.

Laliberté Durish C,Yeates KOBrooks BL.

J Int Neuropsychol Soc. 2018 Sep;24(8):759-768. doi: 10.1017/S1355617718000437. Epub 2018 Sep 7.


Convergent and divergent validity of the Connor-Davidson Resilience Scale in children with concussion and orthopaedic injury.

Laliberté Durish C, Yeates KOBrooks BL.

Brain Inj. 2018;32(12):1525-1533. doi: 10.1080/02699052.2018.1502471. Epub 2018 Jul 26.


Predictors of Long-Term Psychosocial Functioning and Health-Related Quality of Life in Children and Adolescents With Prior Concussions.

Plourde V, Yeates KOBrooks BL.

J Int Neuropsychol Soc. 2018 Jul;24(6):540-548. doi: 10.1017/S1355617718000061. Epub 2018 Mar 21.


Evaluating anxiety and depression symptoms in children and adolescents with prior mild traumatic brain injury: Agreement between methods and respondents.

Plourde V, Daya H, Low TA, Barlow KM, Brooks BL.

Child Neuropsychol. 2019 Jan;25(1):44-59. doi: 10.1080/09297049.2018.1432585. Epub 2018 Jan 30.


Derivation and initial validation of clinical phenotypes of children presenting with concussion acutely in the Emergency Department: Latent class analysis of a multicentre, prospective cohort, observational study.

Yeates KO,Tang K, Barrowman NJ, Freedman SB, Gravel J, Gagnon I, Sangha G, Boutis K, Beeer D, Craig W, Burns E, Farion K, Mikrogianakis A, Barlow KM, Dubrowsky AS, Meeuwisse W, Gioia G, Meehan W, Beauchamp MH, Kamil Y, Grool AM, Hoshizaki B, Anderson P, Brooks BL, Vassilyadi M, Klassen T, Keightley M, Richer L, DeMatteo C, Osmond M, Zemek R.

J Neurotrauma. 2019 Jan 8. doi: 10.1089/neu.2018.6009. [Epub ahead of print]