Pain, calcium channels, receptors, Our broad research focus has been on the roles of voltage gated calcium channels in controlling the electrical activities of neurons and how they are compromised in various neurological disorders. Specific areas include 1) calcium channel structure, function and molecular pharmacology; 2) their regulation by G protein coupled receptors and its physiological consequences; 3) the role of signalling complexes between calcium channels and other channels/receptors; 4) how genetic mutations in calcium channels of patients with epilepsy trigger seizures; and 5) the roles of calcium channels in afferent pain signalling. In addition, our lab uses optogenetics approaches to decipher brain circuits that control sensory and emotional components of pain.
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