Biofilms My lab examines the interaction of biofilm bacteria with both antibiotics and the innate immune system. Current projects are focused on neutrophil functionality, including neutrophil extracellular traps, single-species and multiple species bacterial biofilms (aerobes, microareophiles, and anaerobes), and the innate immune system using in vitro bovine cell models.
Antibiotic Resistance I have historically worked on antibiotic resistance in domestic animals. My lab has worked on applied research evaluating the presence and development of specific types of resistance, CLSI method-based evaluation of antibiotic resistance, and PCR-based detection of specific genes involved in resistance in bacteria isolated from animals (and from humans).
Bacterial Pathogenesis I collaborate with two other research teams evaluating the early pathogenic processes of Mycobacterium avium paratuberculosis using in vitro based organoid (i.e. enteroid) models of bacterial invasion and immune cell function. This work may involve specific murine models of MAP infection.
Immunomodulatory Effects of Antibiotics Several antibiotics have effects on the innate immune system that are distinct from their antibacterial properties. My lab examine the effects and mechanisms of these phenomena within in vitro cell models and within controlled in vivo models of inflammation, such as the murine DSS model of colitis. Current work in this area is evaluating the relationships among DSS induced murine colitis, macrolide and metronidazole exposure in this model, the intestinal (colonic and cecal) microbiome, and neutrophil function. Cell function involves a variety of assessment methods including intravital microscopy.
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