CONTENTS
Main Page Dynamic Development
The Foundations of Developmental
Biology
Gametogenesis
From Sperm and Egg to Embryo
Genetic Regulation of Development
Organizing the Multicellular
Embryo
Generating Cell Diversity
Dynamic Development at a
Glance
Learning Resources
Research Resources
The Developmental Biology Journal
Club
Developmental Biology Tutorial |
Oocyte Maturation
How does an oocyte become an egg?
Learning Objectives
- Review hormonal interactions in mammals and frogs.
- What is unusual about the mechanism of action of progesterone in promoting
oocyte maturation?
- How did Yoshio Masui demonstrate the presence of maturation promotion
factor and cytostatic factor?
- What is MPF, and how was its identity determined?
- What is CSF, and how was its identity determined?
- Review the interactions among p34, cyclin and c-MOS
- What effect does alpha- amanitin have on progesterone-induced amphibian
oocyte maturation? Why?
Digging Deeper:
Recent Literature
de Vantéry, C., Stutz, A., Vassalli, J.D. and Schorderet-Slatkine,
S. 1997. Acquisition of meiotic competence in growing mouse oocytes is controlled
at both translational and posttranslational levels. Develop. Biol. 187:
43-54.
Kume, S., Yamamoto, A., Inoue, T., Muto, A., Okano, H. and Mikoshiba, K.
1997. Developmental expression of the inositol 1,4,5-triphosphate receptor
and structural changes in the endoplasmic reticulum during oogenesis and
meiotic maturation of Xenopus laevis. Develop. Biol. 182: 228-239.
Thibier, C., De Smedt, V., Poulhe, R., Huchon, D., Jessus, C. and Ozon,
R. 1997. In vivo regulation of cytostatic activity in Xenopus
metaphase II-arrested oocytes. Develop. Biol. 185: 55-66.
References
Browder, L.W., Erickson, C.A. and Jeffery, W.R. 1991. Developmental
Biology. Third edition. Saunders College Pub. Philadelphia. |
