Director,
Farncombe Family Institute of Digestive Health Research
McMaster
University
1200 Main Street West, HSC 3N9
Hamilton, Ontario, L8N 3Z5, Canada
Tel: 905-525-9140 ext 22591
Fax: 905-528-9862
E-mail:
wallacejohn@mcmaster.ca
Website:
http://farncombe.mcmaster.ca
Research
My major research interest is
inflammation and the impact that it has on tissue injury and repair of
injury. Most of my work involves studies of inflammation and ulceration
in the gastrointestinal tract, although I also have a long-standing
interest in cardiovascular inflammation and platelet function. I am
particularly interested in identification of novel targets for
anti-inflammatory therapies, and the subsequent development of such
therapies. I was a scientific co-founder of NicOx, a company based in
France which is developing nitric oxide-releasing derivatives of several
classes of drugs (see
www.nicox.com).
More recently, I founded Antibe Therapeutics Inc., which has offices in
Calgary and Toronto (see
www.antibe-therapeutics.com)
and is developing hydrogen sulfide-releasing derivatives of drugs for
inflammatory bowel disease, arthritis, irritable bowel syndrome and
endothelial dysfunction. |
Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself? Physiol Rev. 2008 Oct;88(4):1547-1565.