du reseau de recherches sur l’Inflammation
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Androutsou ME, Saifeddine M, Hollenberg MD, Matsoukas J, Agelis G. 2009.  Design, synthesis and biological evaluation of non-peptide PAR(1) thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. Amino Acids. [Epub ahead of print]

Auge C, Balz-Hara D, Steinhoff M, Vergnolle N, Cenac N. 2009.  Protease-activated receptor-4 (PAR(4)): a role as inhibitor of visceral pain and hypersensitivity. Neurogastroenterol Motil. [Epub ahead of print]

Christianson JA, Bielefeldt K, Altier C, Cenac N, Davis BM, Gebhart GF, High KW, Kollarik M, Randich A, Undem B, Vergnolle N.   2009.  Development, plasticity and modulation of visceral afferents. Brain Res Rev. 60:171-186.

Dale CS, Altier C, Cenac N, Giorgi R, Juliano MA, Juliano L, Zamponi GW, Vergnolle N. 2009.  Analgesic properties of S100A9 C-terminal domain: a mechanism dependent on calcium channel inhibition. Fundam Clin Pharmacol.  23:427-438.

Georgy SR, Pagel CN, Wong DM, Sivagurunathan S, Loh LH, Myers DE, Hollenberg MD, Pike RN, Mackie EJ.  2009. Proteinase-activated receptor-2 and mouse osteoblasts: regulation of cell function and lack of specificity of PAR-activating peptides.  Clin Exp Pharmacol Physiol.  [Epub ahead of print]

Gashev AA, Davis MJ, Gasheva OY, Nepiushchikh ZV, Wang W, Dougherty P, Kelly KA, Cai S, von der Weid PY, Muthuchamy M, Meininger CJ, Zawieja DC.  2009.  Methods for Lymphatic Vessel Culture and Gene Transfection.  Microcirculation22:1-14.

Helyes Z, Sandor K, Borbely E, Tekus V, Pinter E, Elekes K, Toth DM, Szolcsanyi J, McDougall JJ.  2009.  Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception.  Eur J Pain.  [Epub ahead of print]

Hollenberg MD.  2009.  Professor Karl Lederis (1920-2007): always fishing for new ideas.  Gen Comp Endocrinol. 164:4-5.

Hunter DJ, McDougall JJ, Keefe FJ.  2009.  The symptoms of osteoarthritis and the genesis of pain.  Med Clin North Am. 93:83-100.

Imtiaz MS, von der Weid PY, van Helden DF. Synchronization of Ca(2+) oscillations: a coupled oscillator-based mechanism in smooth muscle. FEBS J. 2009 Nov 6. [Epub ahead of print]

Kalischuk LD, Buret AG.  A role for Campylobacter jejuni-induced enteritis in inflammatory bowel disease?  Am J Physiol Gastrointest Liver Physiol. 2009 Oct 29. [Epub ahead of print]

Kalischuk LD, Inglis GD, Buret AG.  2009.  Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts.  Gut Pathog. 1:2.

Kaufmann R, Oettel C, Horn A, Halbhuber KJ, Eitner A, Krieg R, Katenkamp K, Henklein P, Westermann M, Böhmer FD, Ramachandran R, Saifeddine M, Hollenberg MD, Settmacher U.  2009.  Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor 2-mediated hepatocellular carcinoma cell invasion.  Carcinogenesis30:1487-1496.

Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B. 2009.  Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway.  J Immunol. 182:7795-7802.

Lapointe TK, O'Connor PM, Buret AG.  2009.  The role of epithelial malfunction in the pathogenesis of enteropathogenic E. coli-induced diarrhea.  Lab Invest89(9):964-970.

Martin GR, McKnight GW, Dicay MS, Coffin CS, Ferraz JG, Wallace JL.  2009.  Hydrogen sulphide synthesis in the rat and mouse gastrointestinal tract.  Dig Liver Dis [Epub ahead of print]

Martin L, Auge C, Boue J, Buresi MC, Chapman K, Asfaha S, Andrade-Gordon P, Steinhoff M, Cenac N, Dietrich G, Vergnolle N.  2009.  Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways.  Pain.  [Epub ahead of print]

McDougall JJ, Andruski B, Schuelert N, Hallgrimsson B, Matyas JR.  2009.  Unravelling the relationship between age, nociception and joint destruction in naturally occurring osteoarthritis of Dunkin Hartley guinea pigs.  Pain. 141:222-232.

McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N.  2009.  Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice.  Arthritis Rheum. 60:728-737.

McKay DM, Wallace JL.  2009.  Acetic acid induced ulceration in rats is not affected by infection with Hymenolepis diminuta.  J Parasitol. 95:481-482.

Perini RF, Camara PR, Ferraz JG.  2009.  Pathogenesis of portal hypertensive gastropathy: translating basic research into clinical practice.  Nat Clin Pract Gastroenterol Hepatol. 6:150-158.

Pittman QJ, Hollenberg MD.  2009.  Urotensin I-CRF-Urocortins: A mermaid's tail.  Gen Comp Endocrinol. 164:7-14.

Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD.  2009.  Agonist-biased signaling via Proteinase Activated Receptor-2: differential activation of calcium and MAPkinase pathways.  Mol Pharmacol 76(4):791-801.

Roifman I, Sun YC, Fedwick JP, Panaccione R, Buret AG, Liu H, Rostom A, Anderson TJ, Beck PL.  Evidence of endothelial dysfunction in patients with inflammatory bowel disease.  Clin Gastroenterol Hepatol. 7:175-182.

Russell FA, McDougall JJ.  2009.  Proteinase activated receptor (PAR) involvement in mediating arthritis pain and inflammation.  Inflamm Res. 58:119-126.

Sandor K, Bolcskei K, McDougall JJ, Schuelert N, Reglodi D, Elekes K, Petho G, Pinter E, Szolcsanyi J, Helyes Z.  2009.  Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice.  Pain. 141:143-150.

Schuelert N, McDougall JJ. 2009. Grading of monosodium iodoacetate-induced osteoarthritis reveals a concentration-dependent sensitization of nociceptors in the knee joint of the rat.  Neurosci Lett 465(2):184-188.

Swystun VA, Renaux B, Moreau F, Wen S, Peplowski MA, Hollenberg MD, MacNaughton WK. 2009.  Serine proteases decrease intestinal epithelial ion permeability by activation of PKC{zeta}  Am J Physiol Gastrointest Liver Physiol. 297:G60-G70.

van der Merwe JQ, Moreau F, MacNaughton WK.  2009 Protease-activated receptor-2 stimulates intestinal epithelial chloride transport through activation of PLC and selective PKC isoforms. Am J Physiol Gastrointest Liver Physiol. 296:G1258-G1266.

van der Merwe JQ, Ohland CL, Hirota CL, MacNaughton WK.  2009.  Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2.  J Pharmacol Exp Ther. 329:747-752.

Vergnolle N.  2009.  Visceral afferents: What role in post-inflammatory pain?  Auton Neurosci.  [Epub ahead of print]

Vergnolle N.  2009.  Protease-activated receptors as drug targets in inflammation and pain.  Pharmacol Ther. 123:292-309.

Wallace JL.  Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract.  2009. Antioxid Redox Signal.  [Epub ahead of print]

Wallace JL, Viappiani S, Bolla M.  2009.  Cyclooxygenase-inhibiting nitric oxide donators for osteoarthritis.  Trends Pharmacol Sci. 30:112-117.

Wallace JL, Vong L, McKnight W, Dicay M, Martin GR.  2009.  Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.  Gastroenterology. 137:569-578, 578.e1.

Wang H, Zhang R, Wen S, McCafferty DM, Beck PL, MacNaughton WK.  2009.  Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis.  J Mol Med. 87:435-445.

Wilson BJ, Harada R, LeDuy L, Hollenberg MD, Nepveu A.  2009. CUX1 transcription factor is a downstream effector of the proteinase-activated receptor 2 (PAR2).  J Biol Chem. 284:36-45.

Xue M, Hollenberg MD, Demchuk A, Yong VW.   2009.  Relative importance of proteinase-activated receptor-1 versus matrix metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice. Stroke. 40:2199-2204.

Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C.  2009.  CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.  FASEB J [Epub ahead of print]


Alexander CL, Urbanski SJ, Hilsden R, Rabin H, MacNaughton WK, Beck PL. 2008.  The risk of gastrointestinal malignancies in cystic fibrosis Case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus. J Cyst Fibros. 7:1-6.

Alier KA, Endicott JA, Stemkowski PL, Cenac N, Cellars L, Chapman K, Andrade-Gordon P, Vergnolle N, Smith PA.  2008.  Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.  J Pharmacol Exp Ther. 324:224-233.

Andruski B, McCafferty DM, Ignacy T, Millen B, McDougall JJ.  2008.  Leukocyte trafficking and pain behavioural responses to a hydrogen sulphide donor in acute monoarthritis.  Am J Physiol Regul Integr Comp Physiol. 295:R814-R820.

Beye JA, Hart DA, Bray RC, McDougall JJ, Salo PT.  2008.  Injury-induced changes in mRNA levels differ widely between anterior cruciate ligament and medial collateral ligament.  Am J Sports Med. 6:1337-1346.

Buret AG.  2008.  Pathophysiology of enteric infections with Giardia duodenalius.  Parasite. 15:261-265.

Camara PR, Ferraz GJ, Franco-Penteado CF, Sbragia-Neto L, Meirelles LR, Teixeira SA, Muscara MN, Velloso LA, Antunes E, Ferraz JG.  2008.  Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats.  Eur J Pharmacol. 589:245-250.

Cenac N, Altier C, Chapman K, Liedtke W, Zamponi G, Vergnolle N.  2008.  Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.  Gastroenterology. 135:937-46, 946.e1-2.

Chavez-Pina AE, Vong L McKnight W, Dicay M, Zanardo RCO, Ortiz MI, Castañeda-Hernandez G, Wallace JL.  2008.  Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety.  Br J Pharmacol. 155:857-864.

Chin AC, Lee WY, Nusrat A, Vergnolle N, Parkos CA.  2008.  Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration.  J Immunol. 181:5702-5710.

Dale C, Vergnolle N.  2008.  Protease signaling to g protein-coupled receptors: implications for inflammation and pain. J Recept Signal Transduct Res. 28:29-37.

Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL. 2008.  A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner. Am J Physiol Gastrointest Liver Physiol. 295:G374-G381.

Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M.  2008.  Agonists of proteinase-activated receptor-2 enhance IFN-γ inducible effects on human monocytes: Role in influenza A infection. J Immunol. 180:6903-6910.

Flynn AN, Buret AG.  Tight junctional disruption and apoptosis in an in vitro model of Citrobacter rodentium infection. Microb Pathog. 45:98-104.

Flynn AN, Buret AG.  2008.  Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability. Microb Pathog. 44:311-319.

Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.  2008.  Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2 (PAR2): binding and visualization. J Pharmacol Exp Ther. 326:453-462.

Hunter DJ, McDougall JJ, Keefe FJ.  The symptoms of osteoarthritis and the genesis of pain.  Rheum Dis Clin North Am. 34:623-643.

Hyun E, Andrade-Gordon P, Steinhoff M, Vergnolle N.  2008.  Protease-activated receptor-2 activation: a major role in intestinal inflammation. Gut. 57:1222-1229.

Jackson SC, Beck P, Buret AG, O'Connor PM, Meddings J, Pineo G, Poon MC.  2008.  Long term platelet responses to Helicobacter pylori eradication in Canadian patients with immune thrombocytopenic purpura.  Int J Hematol. 88:212-218.

Lamb-Rosteski JM, Kalischuk LD, Inglis GD, Buret AG.  2008.  Epidermal growth factor inhibits Campylobacter jejuni-induced claudin-4 disruption, loss of epithelial barrier function, and Escherichia coli translocation.  Infect Immun. 76:3390-3398.

Liu H, Schuelert N, McDougall JJ, Lee SS. 2008.  Central neural activation of hyperdynamic circulation in portal hypertensive rats depends on vagal afferent nerves. Gut. 57:966-973.

Martin GR, Perretti M, Flower RJ, Wallace JL.  2008.  Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol Gastrointest Liver Physiol. 294:G764-769.

McDougall JJ, Yu V, Thomson J. 2008.  In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints. Br J Pharmacol. 153:358-366.

Miller MJ, Reuter BK, Wallace JL, Sharkey KA.  2008.  A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. J Transl Med. 6:3.

Mrsny RJ, Brown GT, Gerner-Smidt K, Buret AG, Meddings JB, Quan C, Koval M, Nusrat A.  2008.  A key claudin extracellular loop domain is critical for epithelial barrier integrity.  Am J Pathol. 172:905-915.

O'Hara JR, Buret AG.  Mechanisms of intestinal tight junctional disruption during infection. Front Biosci. 13:7008-7021.

Oliveira MS, de O Barreto E, Zamuner S, Pires AL, Ferreira TP, Cordeiro RS, Lagente V, Martins MA, Wallace JL, E Silva PM.  2008.  Suppressive effects of nitric oxide-releasing prednisolone NCX-1015 on the allergic pleural eosinophil recruitment in rats.  Clin Exp Allergy.  38:1830-1837.

Paszcuk AF, Quintao NL, Fernandes ES, Juliano L, Chapman K, Andrade-Gordon P, Campos MM, Vergnolle N, Calixto JB. 2008.  Mechanisms underlying the nociceptive and inflammatory responses induced by trypsin in the mouse paw. Eur J Pharmacol. 581:204-215.

Schuelert N, McDougall JJ. 2008.  Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees. Arthritis Rheum. 58:145-153.

van der Merwe JQ, Hollenberg MD, MacNaughton WK. 2008.  EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 294:G441–G451.

Vergnolle N.  2008.  Proteinase-activated receptors (PARs) in infection and inflammation in the gut. Int J Biochem Cell Biol. 40:1219-1227.

Vergnolle N.  2008.  Postinflammatory visceral sensitivity and pain mechanisms.  Neurogastroenterol Motil. 20:73-80.

von der Weid P-Y, Rahman M, Imtiaz MS, F van Helden DF.  2008.  Spontaneous transient depolarizations in lymphatic vessels of the guinea pig mesentery - pharmacology and implication for spontaneous contractility. Am J Physiol Heart Circ Physiol. 295:H1989-H2000.

Wallace JL.  2008.  Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why doesn't the stomach digest itself?  Physiol Rev. 88:1547-1565.

Wallace JL, Vong L.  2008.  NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs.  Curr Opin Investig Drugs. 9:1151-1156.

Wang H, Wen S, Bunnett NW, Leduc R, Hollenberg MD, MacNaughton WK.  2008.  Proteinase activated-receptor-2 induces cyclooxygenase-2 expression through beta -catenin and cyclic AMP response element binding protein.  J Biol Chem. 283:809-815.

Yu LC, Huang CY, Kuo WT, Sayer H, Turner JR, Buret AG.  2008.  SGLT-1-mediated glucose uptake protects human intestinal epithelial cells against Giardia duodenalis-induced apoptosis. Int J Parasitol. 38:923-934.

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Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C.  2007.  Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. 2007.  J Immunol. 179:5493-5503.

Altier C, Dale CS, Kisilevsky AE, Chapman K, Castiglioni AJ, Matthews EA, Evans RM, Dickenson AH, Lipscombe D, Vergnolle N, Zamponi GW.  2007.  Differential role of N-type calcium channel splice isoforms in pain.  J Neurosci. 27:6363-6373.

Asfaha S, Cenac N, Houle S, Altier C, Papez MD, Nguyen C, Steinhoff M, Chapman K, Zamponi GW, Vergnolle N. 2007.  Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol. 150:176-185.

Buret AG. 2007.  Mechanisms of epithelial dysfunction in giardiasis. Gut. ;56:316-317.

Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N 2007.  Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest. 117:636-647.

Chavez-Pina AE, McKnight W, Dicay M, Castaneda-Hernandez G, Wallace JL.  2007.  Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin.  Br J Pharmacol. 152:930-938.

Coppi LC, Thomazzi SM, Ayrizono MD, Coy CS, Fagundes JJ, Goes JR, Franchi GC Jr, Nowill AE, Montes CG, Antunes E, Ferraz JG. 2007.  Comparative study of eosinophil chemotaxis, adhesion, and degranulation in vitro in ulcerative colitis and Crohn's disease. Inflamm Bowel Dis. 13:211-218.

Fiorucci S, Orlandi S, Mencarelli A, Caliendo G, Santagada V, Distrutti E, Santucci L, Cirino G, Wallace JL.  2007.  Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. Br J Pharmacol. 150:996-1002.

Gillrie MR, Krishnegowda G, Lee K, Buret AG, Robbins SM, Looareesuwan S, Gowda DC, Ho M. 2007.  Src family kinase-dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins. Blood. 110:3426-3435.

Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW.  2007.  Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.  J Physiol. 578(Pt 3):715-733.

Imtiaz MS, Zhao J, Hosaka K, von der Weid PY, Crowe MJ & van Helden DF. 2007.  Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization. Biophys J. 92:3843–3861.

Kalischuk LD, Inglis GD, Buret AG.  2007.  Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin.  Microbiology. 153(Pt 9):2952-2963.

Knecht W, Amadesi S, Mohlin J, Skaregarde A, Geddal K, Peterson A, Chapman K, Hollenberg M, Vergnolle N, Cottrell GS, Bunnett NW. 2007.  Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. J Biol Chem. 282):26089-26100.

Moreira V, Zamuner SR, Wallace JL, Teixeira CD.  2007.  Bothrops jararaca and Crotalus durissus terrificus venoms elicit distinct responses regarding to production of prostaglandins E(2) and D(2), and expression of cyclooxygenases. Toxicon. 49:615-624.

Olivo Rdo D, Teixeira CF, Wallace JL, Gutierrez JM, Zamuner SR.  2007.  Role of cyclooxygenases in oedema-forming activity of bothropic venoms. Toxicon. 49:670-677.

Rattenholl A, Seeliger S, Buddenkotte J, Schon M, Schon MP, Stander S, Vergnolle N, Steinhoff M.  2007.  Proteinase-activated receptor-2 (PAR(2)): A tumor suppressor in skin carcinogenesis.  J Invest Dermatol127:2245-2252.

Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD. 2007.  Proteinase-activated receptor-2 activating peptides: Distinct canine coronary artery receptor systems. Am J Physiol Heart Circ Physiol. 293:H3279-H3289.

Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL. 2007.  Resolution of inflammation: state of the art, definitions and terms. FASEB J. 21:325-332.

Shpacovitch VM, Seeliger S, Huber-Lang M, Balkow S, Feld M, Hollenberg MD, Sarma VJ, Ward PA, Strey A, Gerke V, Sommerhoff CP, Vergnolle N, Steinhoff M.  2007.  Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils.  Exp Dermatol. 16:799-806.

Skinn AC, Vergnolle N, Cellars L, Sherman PM, MacNaughton WK. 2007.  Combined challenge of mice with Citrobacter rodentium and ionizing radiation promotes bacterial translocation. Int J Radiat Biol. 83:375-382.

Tailor A, Wood KC, Wallace JL, Specian RD, Granger DN.  2007.  Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction.  Am J Physiol Heart Circ Physiol. 293:H3636-H3642.

Wallace JL.  2007.  Hydrogen sulfide-releasing anti-inflammatory drugs. 2007. Trends Pharmacol Sci. 28:501-505.

Wallace JL. 2007.  Building a better aspirin: gaseous solutions to a century-old problem. Br J Pharmacol. 152:421-428.

Wallace JL, Caliendo G, Santagada V, Cirino G, Fiorucci S. 2007.  Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat.  Gastro. 132:261-271.

Wallace JL, Dicay M, McKnight W, Martin GR. 2007.  Hydrogen sulfide enhances ulcer healing in rats. FASEB J. 28:501-505.

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Almeida JR, Trevisan L, Guerrazzi F, Mesquita MA, Ferraz JG, Montes CG, Kisilwzky NH, Yamanaka A, Soares EC. 2006.  Bleeding duodenal varices successfully treated with TIPS. 2006;  Dig Dis Sci. 51:1738-1741.

Amadesi S, Cottrell GS, Divino L, Chapman K, Grady EF, Bautista F, Karanjia R, Barajas-Lopez C, Vanner S, Vergnolle N, Bunnett NW.  2006.  Protease-activated receptor 2 sensitizes TRPV1by protein kinase c{epsilon}- and a-dependent mechanisms in rats and mice.  J Physiol. 575:555-571.

Buret AG. 2006.  How stress induces intestinal hypersensitivity.  Am J Pathol. 168:3-5.

Cattaruzza F, Cenac N, Barocelli E, Impicciatore M, Hyun E, Vergnolle N, Sternini C.  2006.  Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents.  Am J Pathol. 169:177-188.

Cirino G, Distrutti E, Wallace JL.  Nitric oxide and inflammation.  Inflamm Allergy Drug Targets. 5:115-119.

Cirino G, Vergnolle N.  2006.  Proteinase-activated receptors (PARs): crossroads between innate immunity and coagulation.  Curr Opin Pharmacol. 6:428-434.

Dale CS, Cenac N, Britto LR, Juliano MA, Juliano L, Vergnolle N, Giorgi R. 2006.  The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2). Br J Pharmacol. 149:374-384.

Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Russo G, Caliendo G, Santagada V, Cirino G, Wallace JL, Fiorucci S.  2006.  5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.  J Pharmacol Exp Ther. 319:447-458.

Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Antonelli E, Roviezzo F, Morelli A, Cirino G, Wallace JL, Fiorucci S.  2006.  Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels.  J Pharmacol Exp Ther. 316:325-335.

Fiorucci S, Distrutti E, Cirino G, Wallace JL.  2006.  The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver.  Gastroenterology. 131:259-271.

Franca AE, Salvino LK, Leite SH, Paraíso Ferraz JG, Rocha TD, Cintra ML, Velho PE, Souza EM.  2006.  Pyoderma gangrenosum as first clinical manifestation of gastric adenocarcinoma.  J Eur Acad Dermatol Venereol. 20:440-441.

Holzhausen M, Spolidorio LC, Ellen RP, Jobin M-C, Steinhoff M, Andrade-Gordon P, Vergnolle N.  2006.  Protease-activated receptor-2 activation a major role in the pathogenesis of porphyromonas gingivalis infection.  Am J Pathol. 1681189-1199.

Hosaka K, Rayner SE, von der Weid PY, Zhao J, Imtiaz MS, van Helden DF.  2006.  Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs. Am J Physiol Heart Circ Physiol. 290:H813-H822.

MacNaughton, WK2006.  Mechanisms and consequences of intestinal inflammation. In: Physiology of the Gastrointestinal Tract, 4th edition. Johnson, L.R., ed. Elsevier. pp 1115-1135.

Martin GR, Wallace JL 2006.  Gastrointestinal inflammation: a central component of mucosal defense and repair.  Exp Biol Med. 231:130-137.

Moormann C, Artuc M, Pohl E, Varga G, Buddenkotte J, Vergnolle N, Brehler R, Henz BM, Schneider SW, Luger TA, Steinhoff M.  2006.  Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells.  J Invest Dermatol126:746-755.

Muscara MN, Wallace JL.  2006.  COX-Inhibiting Nitric Oxide Donors (CINODs): Potential Benefits on Cardiovascular and Renal Function. Cardiovasc Hematol Agents Med Chem. 4:155-164.

Nasser Y, Fernandez E, Keenan CM, Ho W, Oland LD, Tibbles LA, Schemann M, MacNaughton WK, Ruhl A, Sharkey KA.  2006.  The role of enteric glia in intestinal physiology: the effects of the gliotoxin fluorocitrate on motor and secretory function.  Am J Physiol Gastrointest Liver Physiol. 291:G912-G927.

Nelson L, Vergnolle N, D'Mello C, Chapman K, Le T, Swain MG.  2006.  Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated. J Hepatol.  44:1141-1149.

Noorbakhsh F, Tsutsui S, Vergnolle N, Boven LA, Shariat N, Vodjgani M, Warren KG, Andrade-Gordon P, Hollenberg MD, Power C.  2006.  Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis.  J Exp Med. 203:425-435.

O'Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA.  2006.  Consequences of Citrobacter rodentium infection on enteroendocrine signaling and the enteric nervous system in the mouse colon. Cell Microbiol. 8:646–660.

Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.  2006.  Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).   Biol Chem. 387:817-824.

Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.  2006.  Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.  Biol Chem. 387:677-685.

Plaku KJ, von der Weid PY.  2006.  Mast cell degranulation alters lymphatic contractile activity through action of histamine.  Microcirculation. 13:219-227.

Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM. 2006.  Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice. Can J Physiol Pharmacol. 84:1301-1312.

Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.  2006.  A role for proteinase-activated receptor-1 in inflammatory bowel diseases.  J Clin Invest. 116:2056.

Vergnolle N.  2006.  Neuroimmune signalling in the gut - mediators linked to disorders?  Neurogastroenterol Motil. 18:497-498.

Wallace JL.  2006.  COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation.  TSW J 6:577-588.

Wallace JL.  2006.  Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection.  Inflamm Allergy Drug Targets. 5:133-137.

Wallace JL.  2006.  Commonality of defensive roles of COX-2 in the lung and gut.  Am J Pathol 168:1060-1063.

Wallace JL, Dicay M, McKnight W, Dudar GK.  2006.  Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor.  Br J Pharmacol. 148:274-278.

Wu TF, Carati CJ, MacNaughton WK, von der Weid PY.  2006.  Contractile activity of lymphatic vessels is altered in the TNBS model of guinea-pig ileitis.  Am J Physiol Gastrointest Liver Physiol. 291:G566-G574.

Yu LC, Turner JR, Buret AG.  2006.  LPS/CD14 activation triggers SGLT-1-mediated glucose uptake and cell rescue in intestinal epithelial cells via early apoptotic signals upstream of caspase-3.  Exp Cell Res. 312:3276-3286.

Zanardo RC, Brancaleone V, Distrutti E, Fiorucci S, Cirino G, Wallace JL.  2006.  Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation.  FASEB J. 20:2118-2120.

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Andreu-Vieyra CV, Buret AG, Habibi HR.  2005.  Gonadotropin-releasing hormone induction of apoptosis in the testes of goldfish (Carassius auratus).  Endocrinology. 146:1588-1596.

Boisse L, Spencer SJ, Mouihate A, Vergnolle N, Pittman QJ.  2005.  Neonatal immune challenge alters nociception in the adult rat. : Pain. 119:133-141.

Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.  2005.  Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.  J Invest Dermatol. 124:38-45.

Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK. 2005.  Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro. Am J Physiol Gastrointest Liver Physiol. 288:G337-G345.

Buret AG.  2005.  Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction. Mem Inst Oswaldo Cruz. 100:185-90.

Buret AG, Fedwick JP, Flynn AN.  2005.  Host epithelial interactions with Helicobacter pylori: A role for disrupted gastric barrier function in the clinical outcome of infection? Can J Gastroenterol. 19:543-552.

Cenac N, Cellars L, Steinhoff M, Andrade-Gordon P, Hollenberg MD, Wallace JL, Fiorucci S, Vergnolle N. 2005.  Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response.  Inflamm Bowel Dis 11:792-798.

Cenac N, Vergnolle N.  2005.  Proteases and protease-activated receptors (PARs): novel signals for pain.  Curr Top Med Chem. 5:569-576.

Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S, Teskey V, Buret AG.  2005.  Effects of Chondroitin and Glucosamine Sulfate in a Dietary Bar Formulation on Inflammation, Interleukin-1{beta}, Matrix Metalloprotease-9, and Cartilage Damage in Arthritis. Exp Biol Med.  230:255-262.

Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Antonelli E, Roviezzo F, Morelli A, Wallace JL, Cirino G, Fiorucci S.  2005.  Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels. J Pharmacol Exp Ther.  316:325-335.

Fedwick JP, Lapointe TK, Meddings JB, Sherman PM, Buret AG.  2005.  Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun. 73:7844-7852.

Fiorucci S, Antonelli E, Distrutti E, Rizzo G, Mencarelli A, Orlandi S, Zanardo R, Renga B, Di Sante M, Morelli A, Cirino G, Wallace JL.  2005.  Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs.  Gastroenterology. 129:1210-1224.

Hansen KK, Sherman PM, Cellars L, Andrade-Gordon P, Z-Y, Baruch A, Wallace JL, Hollenberg MD, and Vergnolle N.  2005.  A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis.  PNAS 102:8363–8368.

Hollenberg MD, Vergnolle N.  Pharmacotherapy and gastrointestinal disease: where have we been, where are we, and where are we going? Curr Opin Pharmacol. 5:557-558.

Holzhausen M, Spolidorio LC, Vergnolle N.  2005.  Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis.  Mem Inst Oswaldo Cruz. 100:177-180.

Holzhausen M, Spolidorio LC, Vergnolle N.  2005.  Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats.  Dent Res. 84:154-159.

Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N 2005.  Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol. 146:670-678.

Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A.  2005.  Signal transduction for proteinase-activated receptor-2-triggered prostaglandin e2 formation in human lung epithelial cells.  J Pharmacol Exp Ther. 315:576-589.

Lynch T, Livingstone S, Buenaventura E, Lutter E, Fedwick J, Buret AG, Graham D, DeVinney R.  2005.  Vibrio parahaemolyticus disruption of epithelial cell tight junctions occurs independently of toxin production. Infect Immun. 73:1275-1283.

Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg MD, Wallace JL2005.  Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci U S A. 102:216-220.

MacNaughton WK 2005.  Epithelial effects of proteinase-activated receptors in the gastrointestinal tract. Mem Inst Oswaldo Cruz 100:211-215.

Nerland EM, LeBlanc JM, Fedwick JP, Morck DW, Merrill JK, Dick P, Paradis MA, Buret AG.  2005.  Effects of oral administration of tilmicosin on pulmonary inflammation in piglets experimentally infected with Actinobacillus pleuropneumoniae. Am J Vet Res. 66:100-107.

Noorbakhsh F, Vergnolle N, McArthur JC, Silva C, Vodjgani M, Andrade-Gordon P, Hollenberg MD, Power C.  2005.  Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection.  J Immunol. 174:7320-7329.

Panaccione R, Ferraz JG, Beck P.  2005.  Advances in medical therapy of inflammatory bowel disease.  Curr Opin Pharmacol. 5:566-572.

Perini R, Ma L, Wallace JL.  2005.  Roles of platelets and proteinase-activated receptors in gastric ulcer healing.  Dig Dis Sci. 50::S12-S15

Santos CL, Souza MH, Gomes AS, Lemos HP, Santos AA, Cunha FQ, Wallace JL 2005.  Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow. Br J Pharmacol. 146:481-486.

Seymour ML, Binion DG, Compton SJ, Hollenberg MD, MacNaughton WK.  2005.  Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis. Can J Physiol Pharmacol. 83:605-616.

Sigalet DL, Martin GR, Butzner JD, Buret A, Meddings JB.  2005.  A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome.  J Pediatr Surg. 40:763-768.

Skinn AC, MacNaughton WK.  2005.  Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells  Am J Physiol Gastrointest Liver Physiol289:G739–G744.

Steinhoff M, Buddenkotte J, Shpacovitch V, Rattenholl A, Moormann C, Vergnolle N, Luger TA, Hollenberg MD.  2005.  Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1–43

von der Weid PY, Coleman HA.  2005.  Reduced vascular reactivity after chronic nitroglycerine administration: EDHF mechanism is also downregulated.  Br J Pharmacol. 2005;146(4):479-480.

Vergnolle N.  2005.  Protease-activated receptors and inflammatory hyperalgesia.    Mem Inst Oswaldo Cruz. 100:173-6.

Vergnolle N.  2005.  Clinical relevance of proteinase activated receptors (pars) in the gut.   Gut. 54:867-874.

Wallace JL.  2005.  Recent advances in gastric ulcer therapeutics.  Curr Opin Pharmacol. 5:573-577.

Wallace JL.  2005.  Nitric oxide as a regulator of inflammatory processes.  Mem Inst Oswaldo Cruz 100:5-9.

Wallace JL, Devchand PR.  2005.  Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense. Br J Pharmacol. 145:275-282.

Wallace JL, Menezes de Lima O Jr, Fiorucci S.  2005.  Lipoxins in gastric mucosal health & disease.  Prostaglandins Leukot Essent Fatty Acids. ;73:251-255.

Wang HY, MacNaughton WK.  2005.  Overexpressed beta-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells. Cancer Research. 65:8604-8607.

Wu TF, MacNaughton WK, von der Weid PY.  2005.  Lymphatic vessel contractile activity and intestinal inflammation. Mem Inst Oswaldo Cruz. 100:107-110.

Yu LC, Flynn AN, Turner JR, Buret AG.  2005.  SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism? FASEB J. 19:1822-1835.

Zamuner SR, Bak AW, Devchand PR, Wallace JL.  2005.  Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. Am J Pathol. 167:1293-1300.

Zanardo RC, Perretti M, Wallace JL.   2005.  Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol Gastrointest Liver Physiol. 288:G481-G486.

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Alshurafa HN, Stenton GR, Wallace JL, Hollenberg MD, Befus AD, Vliagoftis H.  2004.  A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation.  BMC Pharmacol. 4:12.

Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW.  2004. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.  J Neurosci. 24:4300-4312.

Antony JM, Van Marle G, Opii W, Butterfield DA, Mallet F, Yong VW, Wallace JL, Deacon RM, Warren K, Power C.  2004. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination.  Nat Neurosci. 7:1088-1095.

Cenac N, Chin AC, Garcia-Villar R, Salvador-Cartier C, Ferrier L, Vergnolle N, Buret AG, Fioramonti J, Bueno L.  2004. PAR2 activation alters colonic paracellular permeability in mice via ifn-{gamma}-dependent and -independent pathways.  J Physiol. 558:913-925.

Chan AK, Vergnolle N, Hollenberg MD, von der Weid PY.  2004. Proteinase-activated receptor 2 activation modulates guinea-pig mesenteric lymphatic vessel pacemaker potential and contractile activity.  J Physiol. 560:563-576.

Ferrusi I, Zhao J, van Helden DF, von der Weid P-Y.  2004. Cyclopiazonic acid decreases spontaneous transient depolarizations in guinea-pig mesenteric lymphatic vessels in an endothelium-dependent and independent manner. Am J Physiol Heart Circ Physiol. 286:H2287-H2295.

Fiorucci S, Distrutti E, Mencarelli A, Rizzo G, Lorenzo AR, Baldoni M, Del Soldato P, Morelli A, Wallace JL.  2004. Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence.  J Pharmacol Exp Ther. 309:1174-1182.

Fiorucci S, Wallace JL, Mencarelli A, Distrutti E, Rizzo G, Farneti S, Morelli A, Tseng JL, Suramanyam B, Guilford WJ, Parkinson JF.  2004. A {beta}-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction. Proc Natl Acad Sci U S A. 101:15736–15741.

Flynn AN, Buret AG.  2004. Proteinase-activated receptor 1 (PAR-1) and cell apoptosis.   Apoptosis. 9:729-737.

Freeman SL, MacNaughton WK.  2004. Nitric oxide-inhibitable isoforms of adenylate cyclase mediate epithelial secretory dysfunction following exposure to ionising radiation. Gut. 53:214-221.

Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.  2004. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.  Br J Pharmacol. 143:443-454.

Hyun E, Bolla M, Steinhoff M, Wallace JL, Soldato Pd P, Vergnolle N.  2004. Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis.  Br J Pharmacol. 143:618-625.

Lee WD, Flynn AN, LeBlanc JM, Merrill JK, Dick P, Morck DW, Buret AG.  2004. Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression.  Vet Res. 35:213-224.

MacNaughton WK.  2004. Colitis, Radiation, Chemical, and Drug-Induced. In Encyclopedia of Gastroenterology. Johnson, L.R., Editor. Academic Press. pp 382-384.

MacNaughton WK, van Sickle M, Keenan CM, Cushing K, Mackie K and Sharkey KA.  2004. Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves. Am J Physiol Gastrointest Liver Physiol. 286: G863-G871.

Makhija S, von der Weid PY, Meddings J, Urbanski SJ, Beck PL.  2004. Octreotide in intestinal lymphangiectasia: Lack of a clinical response and failure to alter lymphatic function in a guinea pig model. Can J Gastroenterol. 18:681-685.

Mule F, Pizzuti R, Capparelli A, Vergnolle N.   2004. Evidence for the presence of functional protease activated receptor 4 (PAR(4)) in the rat colon.  Gut. 53:229-234.

Napoli C, De Nigris F, Wallace JL, Hollenberg MD, Tajana G, De Rosa G, Sica V, Cirino G.  2004. Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions.  J Clin Pathol. 57:513-516.

Perini R, Fiorucci S, Wallace JL.  2004. Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: A window of opportunity for cyclooxygenase-inhibiting nitric oxide donors.  Can J Gastroenterol. 18:229-236.

Sayani FA, Keenan CM, van Sickle MD, Amundson KR, Parr EJ, Mathison RD, MacNaughton WK, Braun JEA and Sharkey KA.  2004. The expression and role of Fas ligand in intestinal inflammation. Neurogastroenterol Motil. 16:61-74.

Scott KG, Yu LC, Buret AG.  2004. Role of CD8+ and CD4+ T lymphocytes in jejunal mucosal Injury during murine giardiasis.  Infect Immun. 72:3536-3542.

Shpacovitch VM, Varga G, Strey A, Gunzer M, Mooren F, Buddenkotte J, Vergnolle N, Sommerhoff CP, Grabbe S, Gerke V, Homey B, Hollenberg M, Luger TA, Steinhoff M.  2004. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices.  J Leukoc Biol. 76:388-398.

Vanner S, MacNaughton WK.  2004. Submucosal secretomotor and secretodilator reflexes. Neurogastroenterol Motil16:39-43.

Vergnolle N.  2004. Modulation of visceral pain and inflammation by protease-activated receptors.  Br J Pharmacol. 141:1264-1274.

Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S.  2004. A role for proteinase-activated receptor-1 in inflammatory bowel diseases.  J Clin Invest114:1444-1456.

Vergnolle N, Pages P, Guimbaud R, Chaussade S, Bueno L, Escourrou J, Comera C.  2004. Annexin 1 is secreted in situ during ulcerative colitis in humans.  Inflamm Bowel Dis. 10:584-592.

von der Weid PY, Hollenberg MD, Fiorucci S, Wallace JL.  2004. Aspirin-Triggered, Cyclooxygenase-2-Dependent Lipoxin Synthesis Modulates Vascular Tone.  Circulation. 110:1320-1325.

von der Weid P-Y, Zawieja DC.  2004. Lymphatic smooth muscle: the motor unit of lymph drainage. Int. J. Bioch. Cell Biol. 36:1147-1153.

Wallace JL. 2004. Acetaminophen hepatotoxicity: NO to the rescue. Br J Pharmacol 143:1-2.

Wallace JL, Muscara MN, De Nucci G, Zamuner S, Cirino G, Del Soldato P, Ongini E.  2004. Gastric Tolerability and Prolonged Prostaglandin Inhibition in the Brain with a Nitric Oxide-Releasing Flurbiprofen Derivative (NCX-2216).  J Pharmacol Exp Ther 309:626-633.

Wallace JL, Zamuner SR, McKnight W, Dicay M, Mencarelli A, del Soldato P, Fiorucci S.  2004. Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation.  Am J Physiol Gastrointest Liver Physiol  286:G76–G81.

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Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C.  2003. Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. J Immunol 170:2638-2646.

Buresi MC and MacNaughton WK.  2003. Intestinal epithelial secretory function: role of proteinase-activated receptors. Drug Dev Res  59:386-394.

Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L.  2003. Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J Immunol  170:4296-4300.

Chan, AK, von der Weid P-Y.  2003. 5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT7 receptors. Br J Pharmacol 139:243-254.

Chin ACK, Vergnolle N, MacNaughton WK, Wallace JL, Hollenberg MD and Buret AG.  2003. Proteinase-activated receptor-1 activation induces epithelial apoptosis and increases intestinal permeability. Proc Natl Acad Sci USA 100:11104-11109.

Fiorucci S, Distrutti E, De Lima OM, Romano M, Mencarelli A, Barbanti M, Palazzini E, Morelli A, Wallace JL.  2003. Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J  17:1171-1173.

Fiorucci S, Distrutti E, Mencarelli A, Morelli A, Laufor SA, Cirino G, Wallace JL.  2003. Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.  Br J Pharmacol. 139:1351-1359.

Fiorucci S, Santucci L, Wallace JL, Sardina M, Romano M, Del Soldato P, Morelli A.  2003. Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa.  Proc Natl Acad Sci USA 100:10937-10941.

McDonnell PA, Scott KG, Teoh DA, Olson ME, Upcroft JA, Upcroft P, Buret AG.  2003. Giardia duodenalis trophozoites isolated from a parrot (Cacatua galerita) colonize the small intestinal tracts of domestic kittens and lambs. Vet Parasitol 111:31-46.

Noorbakhsh F, Vergnolle N, Hollenberg MD, Power C.  2003. Proteinase-activated receptors in the nervous system. Nat Rev Neurosci. 4:981-990.

Nguyen C, Coelho AM, Grady E, Compton SJ, Wallace JL, Hollenberg MD, Cenac N, Garcia-Villar R, Bueno L, Steinhoff M, Bunnett NW, Vergnolle N.  2003. Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharmacol 81:920-927.

Pare P, Pearson D, Vergnolle N.  2003. The Canadian Association of Gastroenterology - Are you a member yet? Can J Gastroenterol 17:563-564.

Perini R, Wallace JL.  2003. Proteinase-Activated Receptors (PARs), Platelets and Angiogenesis.  Drug Dev Res 59:395-399.

Perini RF, Ma L, Wallace JL.  2003. Mucosal Repair and COX-2 Inhibition.  Current Pharma Design9:2207-2211.

Seeliger S, Derian CK, Vergnolle N, Bunnett NW, Nawroth R, Schmelz M, Von Der Weid PY, Buddenkotte J, Sunderkotter C, Metze D, Andrade-Gordon P, Harms E, Vestweber D, Luger TA, Steinhoff M.  2003. Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J 17:1871-1885.

Seymour ML, Zaidi NF, Hollenberg MD, MacNaughton WK.  2003. PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin. Am J Physiol Cell Physiol. 284:C1185-C1192.

Sherman PM, Wallace JL.  2003. Should the CAG advocate for resources with government and governmental agencies?  Can J Gastroenterol 17:12-13.

Souza MH, Menezes De Lima Jr O, Zamuner SR, Fiorucci S, Wallace JL.  2003. Gastritis Increases Resistance to Aspirin-Induced Mucosal Injury via COX-2-Mediated Lipoxin Synthesis. Am J Physiol Gastrointest Liver Physiol 85:G54-G61.

Thomson AB, Appleman S, Keelan M, Wallace JL.  2003. Role of gastric mucosal and gastric juice cytokine concentrations in development of bisphosphonate damage to gastric mucosa. Dig Dis Sci. 48:308-314.

Turesin F, Del Soldato P, Wallace JL.  2003. Enhanced anti-inflammatory potency of a nitric oxide-releasing prednisolone derivative in the rat. Br J Pharmacol 139:966-972.

Vergnolle N.  2003. The enteric nervous system in inflammation and pain: the role of proteinase-activated receptors. Can J Gastroenterol. 17:589-92.

Vergnolle N.  2003. The Inflammatory Response.  Drug Dev Res 59:375-381.

Vergnolle N.  2003. Proteinase-Activated Receptors and Nociceptive Pathways.  Drug Dev Res 59: 382-385.

Vergnolle N, Ferazzini M, D'Andrea MR, Buddenkotte J, Steinhoff M.  2003. Proteinase-activated receptors: novel signals for peripheral nerves.  Trends Neurosci 26:496-500.

Wallace JL.  2003. Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease. Dig Liver Dis 35:S35-S40.

Wallace JL, Fiorucci S.  2003. A magic bullet for mucosal protection…and aspirin is the trigger!  Trends Pharmacol Sci 24:323-326.

Wallace JL, Soldato PD.  2003. The therapeutic potential of NO-NSAIDs.  Fundam Clin Pharmacol 17:11-20.

Zamuner SR, Warrier N, Buret AG, MacNaughton WK, Wallace JL  2003. Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction.  Gut 52:1714-1720.

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Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N.  2002. Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol. 135:1101-1106.

Buresi MC, Buret AG, Hollenberg MD, MacNaughton WK.  2002. Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.  FASEB J. 16:1515-1525.

Buret AG, Mitchell K, Muench DG, Scott KGE.  2002. Giardia lamblia disrupts tight junctional ZO-1 and increases permeability in non transformed human small intestinal epithelial monolayers: Effects of epidermal growth factor. Parasitology 125:11-19.

Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.   2002. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.  Am J Pathol 161:1903-1915.

Chin AC, Teoh DA, Scott KG-E, Meddings JB, MacNaughton WK, Buret AG.  2002. Strain-dependent induction of enterocyte apoptosis by Giardia lamblia disrupts epithelial barrier function in non-transformed human duodenal monolayers. Infect Immun. 70:3673-3680.

Coelho AM*, Vergnolle N*, Guiard B, Fioramonti J, Bueno L.  2002. Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology. 122:1035-1047. * First co-authors.

Ecclissato C, Marchioretto MA, Mendonca S, Godoy AP, Guersoni RA, Deguer M, Piovesan H, Ferraz JG, Pedrazzoli J.  2002. Increased primary resistance to recommended antibiotics negatively affects Helicobacter pylori eradication. Helicobacter. 7:53-59.

Fiorucci S, De Lima OM Jr, Mencarelli A, Palazzetti B, Distrutti E, McKnight W, Dicay M, Ma L, Romano M, Morelli A, Wallace JL.  2002. Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage.  Gastroenterology. 123:1598-1606.

Fox JLR, von der Weid, P-Y.  2002. Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery. Br J Pharmacol.  136:1210-1218.

Ma L, Del Soldato P, Wallace JL.  2002. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance.  Proc Natl Acad Sci 99:13243-13247.

McQuibban GA, Gong JH, Wong JP, Wallace JL, Clark-Lewis I, Overall CM.  2002. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.  Blood. 100:1160-1167.

Miceli P, Morris GP, MacNaughton WK, Vanner S.  2002. Alterations in capsaicin-evoked electrolyte transport during the evolution of guinea pig TNBS ileitis.  Am J Physiol Gastrointest Liver Physiol. 282:G972-G980.

Olson ME, Ceri H, Morck DW, Buret AG, Read, RR.  2002. Biofilm bacteria: Formation and comparative susceptibility to antibiotics. Can J Vet Res. 66:86-92.

Ortiz RA, Calafatti SA, Corazzi A, Souza JM, Deguer M, De Souza CA, Marchioretto MA, Bernasconi G, Ferraz JG, Pedrazzoli J Jr.  2002. Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole. Aliment Pharmacol Ther. 16:1163-1170.

Rossoni G, Muscara MN, Cirino G, Wallace JL.  2002. Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit.  Br J Pharmacol. 135:1540-1546

Scott K G-E, Kirk DR, Meddings JB, Lees-Miller SP, Buret AG.  2002. Intestinal infection with Giardia sp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion.  Gastroenterology 123:1179-1190.

Vergnolle N, Derian CK, D'andrea MR, Steinhof M, Andrade-Gordon P.  2002. Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-4.  J Immunol. 169:1467-1473.

Wallace JL.  2002. Selective cyclooxygenase-2 inhibitors: after the smoke has cleared.  Digest Liver Dis. 34:89-94

Wallace JL, Ignarro LJ, Fiorucci S.  2002. Potential cardioprotective actions of NO-Releasing aspirin.  Nature Reviews 1:375-382.

Wright JB, Lam K, Buret AG, Olson ME, Burrell RE.  2002. Early healing events in a porcine model of contaminated wounds: Effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Rep. Regen. 10:141-151.

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Ajuebor MN, Hogaboam CM, Kunkel SL, Proudfoot AE, Wallace JL.  2001. The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.  J Immunol. 166:552-558.

Asfaha S, MacNaughton WK, Appleyard CB, Chadee K, Wallace JL. 2001. Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 281:G635-G644.

Buresi MC, Schleihauf E, Vergnolle N, Buret A, Wallace JL, Hollenberg MD, MacNaughton WK.  2001. Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 281:G323-G332.

de Garavilla L, Vergnolle N, Young SH, Ennes H, Steinhoff M, Ossovskaya VS, D'Andrea MR, Mayer EA, Wallace JL, Hollenberg MD, Andrade-Gordon P, Bunnett NW.  2001. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 133:975-987.

Ecclissato C, Carvalho AF, Ferraz JG, de Nucci G, De Souza CA, Pedrazzoli J Jr.  2001. Prevalence of peptic lesions in asymptomatic, healthy volunteers. Dig Liver Dis. 33:403-406.

Fiorucci S, Distrutti E, Ajuebor MN, Mencarelli A, Mannucci R, Palazzetti B, Del Soldato P, Morelli A, Wallace JL.  2001. NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. Am J Physiol Gastrointest Liver Physiol. 281:G654-G665.

Freeman SL, Hossain M, MacNaughton WK.   2001. Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret.   Int J Radiat Biol. 77:389-395.

Giuliano F, Ferraz JG, Pereira R, de Nucci G, Warner TD. 2001. Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation. Eur J Pharmacol. 426:95-103.

Ma L, Elliott SN, Cirino G, Buret A, Ignarro LJ, Wallace JL.  2001. Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release. Proc Natl Acad Sci U S A. 98:6470-6475

Miller MJ, Vergnolle N, McKnight W, Musah RA, Davison CA, Trentacosti AM, Thompson JH, Sandoval M, Wallace JL.  2001. Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado. J Invest Dermatol. 117:725-730.

Muscara MN, Lovren F, McKnight W, Dicay M, del Soldato P, Triggle CR, Wallace JL. 2001. Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. Br J Pharmacol. 133:1314-1322.

O'Handley RM, Buret AG, McAllister TA, Jelinski M, Olson ME.  2001. Giardiasis in dairy calves: effects of fenbendazole treatment on intestinal structure and function.   Int J Parasitol. 31:73-79.

Pedrazzoli J Jr, Calafatti SA, Ortiz RA, Dias FE, Deguer M, Mendes FD, Bento AP, Pereira AA, Piovesana H, Ferraz JG, Lerner F, de Nucci G.  2001. Transfer of clarithromycin to gastric juice is enhanced by omeprazole in Helicobacter pylori-infected individuals. Scand J Gastroenterol. 36:1248-53.

Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL2001. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med 7:821-826.

Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD.  2001. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci. 22:146-152.

von der Weid P-Y.   2001. Lymphatic vessel pumping and inflammation -The role of spontaneous constrictions and underlying electrical pacemaker potential. Aliment Pharmacol Ther15:1115-1129.

von der Weid P-Y, Zhao J, Van Helden DF.  2001. Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery.  Am J Physiol Heart Circ Physiol. 280:H2707-H2716.

Wallace JL.  2001. Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract.  Mechanisms of protection and healing: current knowledge and future research.   Am J Med. 110:19S-23S.

Wallace JL, Muscara MN.  2001. Selective cyclo-oxygenase-2 inhibitors: cardiovascular and gastrointestinal toxicity. Digest Liver Dis. 33:S21-S28.

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Ajuebor MN, Singh A, Wallace JL.  2000. Cyclo-oxygenase-2-derived prostaglandin D2 is an early anti-inflammatory signal in experimental colitis.  Am J Physiol279:G238-G244.

Barnett K, Bell CJ, McKnight W, Dicay M, Sharkey KA and Wallace J.  2000. Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach.  Am J Physiol  279:G1292-G1297.

Brandao CG, Ferreira HH, Piovesana H, Polimeno NC, Ferraz JG, de Nucci G, Pedrazzoli J Jr. 2000. Development of an experimental model of liver cirrhosis in rabbits. Clin Exp Pharmacol Physiol. 27:987-990.

Calafatti SA, dos Santos A, da Silva CM, Deguer M, Carvalho AF Jr, Mendes FD, Ferraz JG, Bento AP, Pereira AA, Piovesana H, de Nucci G, Lerner F, Pedrazzoli J Jr.  2000. Transfer of metronidazole to gastric juice: impact of Helicobacter pylori infection and omeprazole. Scand J Gastroenterol. 35:699-704.

Chin AC, Lee WD, Murrin KA, Morck DW, Merrill JK,Dick P, Buret AG.  2000. Tilmicosin induces apoptosis in bovine peripheral neutrophils in the presence or in the absence of Pasteurella haemolytica and promotes neutrophil phagocytosis by macrophages. Antimicrob Ag Chemother. 44:2465-2470. 

Freeman SL, MacNaughton WK2000. Ionizing radiation induces iNOS-mediated epithelial dysfunction in the absence of an inflammatory response.  Am J Physiol 278:G243-G250.

Goubau S, Morck DW, Buret A.  2000. Tilmicosin does not inhibit interleukin-8 gene expression in the bovine lung experimentally infected with Mannheimia (Pasteurella) haemolytica.  Can J Vet Res. 64:238-242.

Koch CC, Esteban DJ, Chin AC, Olson ME, Read RR, Ceri H, Morck DW, Buret A.  2000. Apoptosis, oxidative metabolism, and Interleukin-8 production in human neutrophils exposed to azithromycin: Effects of Streptococcus pneumoniae.  J Antimicrob Chemother 46:19-26.

Ma L, Wallace JL.  2000. Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Am J Physiol 279:G341-G346.

MacNaughton WK, Cushing K.  2000. Role of constitutive cyclooxygenase-2 in prostaglandin-dependent secretion in mouse colon in vitro.  J Pharmacol Exp Therap 293:539-544.

Meirelles-Santos JO, Carvalho AF Jr, Callejas-Neto F, Magna LA, Yamanaka A, Zeitune JM, Brandalise NA, Ferraz JG.  2000. Absolute ethanol and 5% ethanolamine oleate are comparable for sclerotherapy of esophageal varices. Gastrointest Endosc. 51:573-576.

Miller MJS, MacNaughton WK, Zhang X-J, Thompson JH, Charbonnet RM, Bobrowski P, Lao J, Trentacosti AM, Sandoval M.  2000. Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado.  Am J Physiol  279:G192-G200.

Muscara MN, Lovren F, Triggle CR, Cirino G, Wallace JL.  2000. Anti-hypertensive properties of a nitric oxide-releasing naproxen derivative in 2-kidney, 1-clip rats.  Am J Physiol 279:H528-H535.

Muscara MN, McKnight W, Asfaha S, Wallace JL.  2000. Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor. Br J Pharmacol129:681-686. 

Scott KG-E, Logan MR, Klammer GM, Teoh DA, Buret AG.  2000. Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6.  Infect Immun 68:3412-3418.

Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW.  2000. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nature Med. 6:151-158.

Teoh D, Kamieniecki D, Pang G, Buret A.  2000. Giardia lamblia rearranges F-actin and alpha-actinin in human colonic and duodenal monolayers and reduces transepithelial electrical resistance. J Parasitol. 86:800-806.

Van Helden DF, Imtiaz MS, Nurgaliyeva K, von der Weid P-Y, Dosen PJ.  2000. Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus. J Physiol (Lond) 524:245-265.

Vliagoftis H, Schwingshackl A, Milne CD, Duszyk M, Hollenberg MD, Wallace JL, Befus AD, Moqbel R.  2000. Proteinase-activated receptor-2-mediated matrix metalloproteinase-9 release from airway epithelial cells.  J Allergy Clin Immunol. 106:537-545.

Wallace JL.  McKnight W, Reuter BK, Vergnolle N.  2000. NSAID-Induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology. 119:706-714.

Wallace JL.  Miller MJ.  2000. Nitric oxide in mucosal defense: a little goes a long way. Gastroenterology. 119:512-520.

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