Ron Mathison, PhD
BSc (University of Calgary), PhD (University
of Calgary)
Adjunct
Associate Professor
Département de Physiologie et
Pharmacologie
3330 Hospital Drive NW
Calgary, Alberta, Canada T2N 4N1
Tel: 403-220-6896
Fax: 403-283-4740
E-mail:
rmathiso@ucalgary.ca
A Member of the
Gastrointestinal Research Group
Research
I have
identified several novel hormones in the rat submandibular glands that
markedly attenuate the severity of endotoxic and anaphylactic shock. These
hormones are called submandibular gland peptides-T (SGP-T) and –S (SGP-S). A
peptide of particular interest is an analogue of SGP-T, the tripeptide FEG,
which is a potent inhibitor of allergic reactions. Current studies focus
around the FEG tripeptide with characterization of its profile of biological
activity, identification of its mechanism of action, and characterization
and localization of its receptors. Techniques related to animal models of
inflammation, cell biology, receptor binding and molecular modeling are
used. |
Home