Ron Mathison, PhD                                                                                                                                   
BSc (University of Calgary), PhD (University of Calgary)
 

Adjunct Associate Professor
Department of Physiology and Pharmacology
3330 Hospital Drive NW
Calgary, Alberta, Canada T2N 4N1

Tel: 403-220-6896
Fax: 403-283-4740
E-mail: rmathiso@ucalgary.ca

Research

I have identified several novel hormones in the rat submandibular glands that markedly attenuate the severity of endotoxic and anaphylactic shock. These hormones are called submandibular gland peptides-T (SGP-T) and –S (SGP-S). A peptide of particular interest is an analogue of SGP-T, the tripeptide FEG, which is a potent inhibitor of allergic reactions. Current studies focus around the FEG tripeptide with characterization of its profile of biological activity, identification of its mechanism of action, and characterization and localization of its receptors. Techniques related to animal models of inflammation, cell biology, receptor binding and molecular modeling are used.

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