Department of Physiology & Pharmacology
Office: HSC 2113 (403) 220-7585
Lab: HSC 2077 (403) 210-9307
Fax number: (403) 283-2700
The goal of my lab is to understand how physiological and behavioural challenges lead to long-term changes in neural circuitry. We focus on neurons that coordinate an organism's response to stress, with a particular interest in clarifying how the molecules released at the onset of a stressful stimulus leave a lasting imprint on how ‘stress-relevant' ciruitry functions. Within this context, we conduct experiments that will allow us to understand the fundamental rules that govern cell to cell communication within the hypothalamus and elucidate the molecular machinery that contributes to changes in synaptic function which, in turn, may be critical for changing network output.
We are currently exploring three lines of investigation:
We use a number of experimental techiques to answer the above questions. These include, but are not limited to: patch clamp recordings from neurons in brain slices for the measurement of excitatory and inhibitory synaptic currents; UV laser uncaging of bioactive molecules; immunohistochemistry for the labeling of receptors and neuronal subpopulations.
Key words describing research:
synaptic transmission, synaptic plasticity, stress, electrophysiology, patch-clamp, synapse, glia, neuron, GABA, glutamate, hypothalamus, neuroscience
patch clamp recordings from neurons in brain slices, UV laser uncaging of bioactive molecules, immunohistochemistry, in vivo microinjection, behavioural manipulations and hormone assays
Canadian Institutes of Health Research (CIHR)
Heart & Stroke Foundation of Canada (HSFC)
Tara Miller, email@example.com (403) 220-6617