Microbiology, Immunology & Infectious Diseases
ProfessorMedicine Oncology Microbiology, Immunology & Infectious Diseases (MIID) Address: HSC 2560, 3330 Hospital Drive N.W. Calgary, Alberta, Canada T2N 4N1 Phone: 403-210-8630 (office) / 403-220-7671 (lab) BMT Clinic: 403-521-3463 Fax: (403) 210-8176 Email: firstname.lastname@example.org
1978-1984 Charles University School of General Medicine, Prague, Czech Republic,
MUDr (MD equivalent, 1984) and CSc (PhD equivalent, 1994)
1984-1994 Research and Clinical Trainee (Internal Medicine, Hematology, Medical Oncology, Hematopoietic Cell Transplantation, Immunology), Charles University Hospital, Prague, University of California, Los Angeles, University of Washington, Seattle, and Fred Hutchinson Cancer Research Center, Seattle
1994-2004 Staff, Fred Hutchinson Cancer Research Center and University of Washington, Seattle
2004-Present Associate and Full Professor, Departments of Medicine (Hematology), Oncology and Microbiology/Immunology/Infectious Diseases, University of Calgary, and Alberta Blood and Marrow Transplant Program, Alberta Health Services
Immunity of Hematopoietic Cell Transplant Recipients
Hematopoietic cell transplantation is used to treat hematologic malignancies, aplastic anemia and congenital defects of hematopoiesis. The most frequent complications are immune complications. These include either insufficient immunity against microorganisms or leukemic cells, leading to infections or leukemic relapse, or deleterious immunity leading to, e.g., graft-versus-host disease.
We study how immunity develops after hematopoietic cell transplantation. This includes evaluation of immunity against virus-infected cells or leukemic cells, with the goal of limiting the incidence of infections and relapse. It also includes evaluation of alloimmunity, autoimmunity and allergy. For example, we search for biomarkers of graft-vs-host disease, with the goal of improving donor selection or treating graft-vs-host disease preemptively. For another example, we explore whether and how allergic diseases (asthma, rhinitis, eczema) or autoimmune diseases are transferred from a hematopoietic cell donor to a recipient, or cured if a hematopoietic cell transplant recipient with an autoimmune or allergic disease receives the graft from a healthy donor.
Outstanding students are welcome to apply for studies under my supervision toward PhD, MD+PhD (only students who have been accepted to the MD program at the University of Calgary), or Residency+PhD (only MDs who have been accepted to University of Calgary as internal medicine, hematology, oncology or infectious diseases residents). First year BHSC students interested in a project or summer studentship under my supervision are also encouraged to apply. Applications should be in the form of an email explaining why you are interested; Resume/Curriculum Vitae should be attached.