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Pierre-Yves von der Weid, PhD

pierre-yves-von-der-weid

Associate Professor
Department of Physiology and Pharmacology

3330 Hospital Drive NW
Calgary, Alberta, T2N 4N1
Phone: (403) 220-7967    Fax: (403) 283-3840
E-mail: vonderwe@ucalgary.ca

Diploma in Biology (University of Geneva)
D Phil (University of Geneva)


 

Research
The lymphatic system is composed of a dense network of lymphatic vessels, which plays a vital role in physiological processes such as tissue fluid homeostasis and transport of antigens and immune cells to and from lymphoid tissue. These two functions are critically important during inflammation to minimize the associated edema and initiate the immune response. My research program is focused on the physiology of lymphatic vessels and mechanisms related to the propulsion of lymph and alteration of these functions during inflammation. Investigations are articulated around four major axes:

Mechanisms of generation and modulation of lymphatic pumping.

  • Generation of lymphatic pumping – origin of pacemaker potentials.
  • Role of the endothelium and endothelium-released factors in modulation of lymphatic pumping.
  • Modulation of lymphatic pumping and pacemaker potentials by vasoactive and inflammatory mediators.

Basis of mechanical stimulation of lymphatic pumping.

  • Modulation of lymphatic pumping and pacemaker potentials by vessel distention and transmural pressure.
  • Identification of lymphatic mechanosensitive mechanisms.

Chemical communication between lymphatic vessels and neighbouring tissues and cells.

  • Cross-talk between blood and lymphatic vessels.
  • Interactions with immune cells.

Lymphatic vessel functions in animal models of inflammation.

  • Alteration of lymphatic contractility during intestinal inflammation.
  • Role of COX metabolites.


Click here to view PubMed entries for Pierre-Yves von der Weid.

Administrative Assistant
Barbara Chyz
Phone: (403) 220-4555
E-mail: chyz@ucalgary.ca

Support provided by the Lymphedema Research Education Program.