The Gastrointestinal Research Group
Professor, Departments of Physiology & Pharmacology
BSc (Hons), University of London
PhD, University of Liverpool
My research activities focus on the role of nerves in the gastrointestinal (GI) tract in health and in models of disease. My research spans studies from the brainstem control of GI function in normal animals, to studies of the role of enteric glia in conditions of intestinal inflammation. The GI tract has a dual autonomic innervation and its own, enteric nervous system. The relative roles the different neural components of the gut make to physiological and pathophysiological processes in the intestine is only now being fully understood. My studies seek to explore further both these groups of nerves in the function of the GI tract in health and in inflammatory diseases of the GI tract. Details of these projects can be found at: http://www.acs.ucalgary.ca/~ksharkey/
Robertson MA, Sigalet DL, Holst JJ, Meddings JB, Wood J, Sharkey KA. Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study. J Autism Dev Disord Feb 29, 2008.
Miller MJ, Reuter BK, Wallace JL, Sharkey KA. A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. J Transl Med 6:3, 2008.
Krauter EM, Strong DS, Brooks EM, Linden DR. Sharkey KA, Mawe GM. Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig. Neurogastroenterol Motil 19(12): 990-1000, 2007.
Chambers AP, Vemuri VK, Peng Y, Wood JT, Olszewska T, Pittman QJ, Makriyannis A, Sharkey KA. A neutral CB1 receptor antagonist reduces weight gain in rat. Am J Physiol Regul Integr Comp Physiol 293(6): R2185-93, 2007.
Nguyen H, Wang H, Le T, Ho W, Sharkey KA, Swain MG. Downregulated hypothalamic 5-HT3 receptor expression enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats. Neurogastroenterol Motil 20(3): 228-35, 2008.