The Gastrointestinal Research Group
Assistant Professor, Departments of Medicine (Division of Gastroenterology)
and Microbiology & Infectious Diseases
B.Sc. (Honours) Biochemistry, University of Saskatchewan;
Ph.D. Gastrointestinal Immunophysiology, University of Calgary;
M.D. University of Calgary
In general, I am interested in learning more about the composition and ecology of bacterial communities in the intestinal tract, and the role of gut bacteria in human health and disease. Considering that most intestinal bacteria cannot be grown in culture, my work relies heavily on DNA-based methods for identifying the constituent members of these complex bacterial communities. The methods for describing and analyzing the intestinal microbiota are rapidly advancing, making this a promising and exciting field to be a part of. My clinical practice is dedicated to the care of patients with Inflammatory Bowel Disease (Crohn's disease and ulcerative colitis) which has inspired my specific aim to study bacterial triggers of intestinal inflammation. I am also interested in the potential of various pharmaceutical, prebiotic, and probiotic agents to favorably alter the community of gut bacteria to reduce intestinal inflammation. I work with colleagues in the Faculty of Veterinary Medicine studying Mycobacterium paratuberculosis, a cause of granulomatous intestinal inflammation in animals that has also been associated with human Crohn's disease.
J Kaufman, T Griffiths, M Surette, S Ness, KP Rioux. Effects of mesalamine (5-aminosalicylic acid) on bacterial gene expression. Inflamm Bowel Dis 2009; Feb 7. [Epub ahead of print]
Rioux KP. What is the prognosis of ulcerative colitis? Inflamm Bowel Dis 2008;14(Suppl. 2):S52-3, 2008.
Griffiths T, Rioux KP, and De Buck J. Sequence polymorphisms in a surface PPE protein distinguish types I, II, and III of Mycobacterium avium subsp. paratuberculosis. J Clinical Microbiology 46:1207-12, 2008.
Rioux KP and Fedorak RN. Probiotics in Inflammatory Bowel Disease. J Clin Gastroenterol 2006;40:260-263.