Research Area My research combines integrated physiology and neuroscience in order to understand cardiovascular function. Currently, the laboratory has two primary foci: the first is to understand the mechanisms underlying neurovascular regulation in the human brain; the second is to develop a neurostimulation therapy for restoring cardiovascular health in those with autonomic dysfunction.
Collaborations I am currently collaborating with labs in Switzerland and Croatia as well as with clinicians in Minnesota to deeply understand the capacity of electrical stimulation of the spinal cord to control autonomic function. These studies are using murine models, as well as non-human primates and humans.
Tools Clinical tools used in the lab include vascular and cardiac ultrasound, beat-by-beat blood pressure, MRI, orthostatic stress testing, arterial blood gas reactivity testing, both surgically implanted and non-invasive neurostimulation modalities, etc. Preclinical tools include CLARITY (tissue clearing method), arterial cannulation, spinal cord transection/contusion, and a variety of genetic strains for optogenetic manipulation (e.g., Th-Cre, PV-Cre). The lab is also employing a novel computational pipeline for managing large data-sets of physiological metrics.
Trainees Trainees at all stages will have the opportunity to be a primary author on published peer reviewed manuscripts, participate in national and international field-work, and gain experience in translational integrated physiology and neuroscience.
This supervisor is currently seeking students.
Trainees at the postdoctoral, graduate or undergraduate level interested in these areas of research are encouraged to send their CV and a letter of interest to Courtney Hubl: firstname.lastname@example.org
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