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Dr. Brent Winston

 

Brent W. Winston, M.D., FRCPC, FACP, FCCP, FCCM
Associate Professor
Cumming School of Medicine, University of Calgary

 

Departments:

Critical Care Medicine, Medicine, Biochemistry and Molecular Biology 
 

Member: Immunology Research Group, Airway Inflammation Group

                  Snyder Institute for Chronic Diseases
 

Associate Member: Cancer Biology Research Group


Research:

 

The research focus in my laboratory has been directed toward macrophage functional differentiation, specifically towards inflammatory gene regulation in macrophages.  For example, when murine bone marrow-derived macrophages are exposed to TNFα, they upregulate a set of genes (IGF-I is one example) and differentiate towards a pathway which may take part in wound repair/fibrosis. However, when these same macrophages are exposed to TNFα in the presence of interferons (IFN's), they differentiate along a pathway which upregulates inflammatory genes like the alternative complement cascade factor B (Bf) or inducible nitric oxide synthase (iNOS). Each of these pathways may have disease related implications.  For example, Bf is an important complement factor in the activation of the alternative complement cascade in sepsis, whereas IGF-I may play an important role in pulmonary fibroproliferation (scar formation in the lungs). Research in my laboratory has remained focused on macrophage functional differentiation, particularly on two main related themes:

 

  • Insulin-like growth factor-I (IGF-I) gene regulation and induction in fibrotic lung diseases.  We are involved in both human and murine studies to examine the role of IGF-I on pulmonary fibroproliferation.
  • Alternative complement cascade Factor B gene regulation and induction in sepsis.  We are involved in human studies and use murine in vivo models to examine the role of the alternative complement cascade, specifically factor B, in shock and organ dysfunction in sepsis.

 

My laboratory is well positioned to conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.

 

Administrative assistant:

Leslie Cooper
Email address: cooperl@ucalgary.ca
Phone number: 403 220.4341